This is no myth.. how one can OD on pot.
Clinical Pharmacology
Although it is a potent drug that may produce psychoactive effects, THC (and the other cannabinoids) have relatively low toxicity and lethal doses in humans have not been described.[23,24] The theoretical
lethal dose in 50 percent (LD50) is estimated to be 1 to 20,000 or 1 to 40,000. Thus, it would require
1500 pounds of cannabis smoked in fifteen minutes to induce a lethal effect.[25]
Central effects of cannabinoids include disruption of psychomotor behavior, short-term memory impairment, intoxication, stimulation of appetite, antinociceptive actions (particularly against pain of neuropathic origin) and anti-emetic effects. Although there are signs of mild cognitive impairment in chronic cannabis users there is little evidence that such impairments are irreversible, or that they are accompanied by drug-induced neuropathology. A proportion of regular users of cannabis will develop some tolerance. A study by Hart and colleagues demonstrated that acute cannabis smoking produced minimal effects on complex cognitive task performance in experienced cannabis users, while still subjectively providing a euphoric "high".[38] The potential medical applications of both natural and synthetic cannabinoids are currently being tested in a number of clinical trials.
Ahhh.. but what a way to go...
