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Ajulemic Acid (IP-751): Synthesis, Proof Of Principle, Toxicity Studies, And Clinical

Julie Gardener

New Member
Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials​
Summer Burstein
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, 01605 Worcester, MA
Summer Burstein, Phone: (508) 856-2850, Fax: (508) 856-2003, Email: sumner.burstein@umassmed.edu.
Corresponding author.
AAPS J. 2005 March; 7(1): E143—E148.
Published online 2005 June 29. doi: 10.1208/aapsj070115.
PMCID: PMC2751505
Copyright © American Association of Pharmaceutical Scientists 2005
Received September 27, 2004; Accepted December 12, 2004.
This article has been cited by other articles in PMC.


Ajulemic acid (CT-3, IP-751,1',1'-dimethylheptyl-Δ8 acid) (AJA) has a cannabinoid-derived structure; however, there is no evidence that it produces psychotropic actions when given at therapeutic doses. In a variety of animal assays, AJA shows efficacy in models for pain and inflammation. Furthermore, in the rat adjuvant arthritis model, it displayed a remarkable action in preventing the destruction of inflamed joints. A phase-2 human trial with chronic, neuropathic pain patients suggested that AJA could become a useful drug for treating this condition. Its low toxicity, particularly its lack of ulcerogenicity, further suggests that it will have a highly favorable therapeutic index and may replace some of the current anti-inflammatory/analgesic medications. Studies to date indicate a unique mechanism of action for AJA that may explain its lack of adverse side effects.

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