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Alzheimer's Disease: Preventing & Halting Progression With Ultra Small Doses

Guy Cavallero

Well-Known Member
Hi all.....
I wanted to once again step out of the shadows and thank @SweetSue for some behind-the-scenes information and inspiration that she has once again shared with me........
I will now share our experience with you all.

About 2 years ago, my girlfriend's brother started to show signs that something was bothering him. He had lost his job, quietly, nobody knew about it other than him and his family. Apparently this had to do with an incident at work and an accident that happened on a nearby Road. Needless to say, he was let go of his position after 15 years, but nobody really started to put the pieces together. Basically Dave had forgotten whether or not he had done his Circle check on his vehicle before he got in. (No nobody was hurt in the accident that he was in....just himself....inside). Proud man, a man that had provided for his mom, and sisters when he lost his dad. Dave was 11 at the time.

Throughout the past year, we had definitely noticed that something was bothering him and that he was becoming a very secretive and internal person, which was an exact opposite of the man that I had met just a short time before. Always outgoing and bubbly, to throw a Sucker Punch into your stomach kind of guy if you know what I mean LOL.

I had had the opportunity about six months ago to sit down and discuss things with Dave. Not using technical terms or anything but trying to get some information out of him to see if I could figure out what was going on. To me, his memory loss, his slurring of words and forgetfulness of what he was talking about all seemed to lead to the early onset of Alzheimer's disease.

After months of harassing him, is finally got his opportunity to get in for an MRI test. The MRI took about three weeks to get back but sure enough Dave has been diagnosed with Cortical Posterior Atrophy (CPA) or a more refined and rarer version of Alzheimer's disease. The worst part about the disease is that your mind stays sharp, you just see your body starting to deteriorate and you realize that your mind isn't working correctly even though your thoughts are clear (to you).

After a bit of butting heads, Dave agreed to start taking CBD on a daily basis. But, with as with any skeptic and, after seven days he came to me and told him that his month supply was gone LMAO. Needless to say, we concluded that the CBD alone was not working. I recently had the opportunity to harvest my CBDurban, which is an 8: 8 CBD / THC strain. With the help of some calculations behind the scene from Sue and IntheShed, I was able to conclude that my CBD /THC capsules worked out to be about 7 mg/ size 00 capsule. This was all done using my MB2 machine, after decarbing 6 ozs of dry bud.

Dave started on the new capsules about a week ago.

On the weekend, we all recognized this past Sunday as Mother's Day. Needless to say we had a few phone calls to the house as we live with my mother-in-law. Halfway through the day, Dave called..... had a conversation with his mother, wished her happy Mother's Day and that was that. We all asked how he sounded, my mother-in-law said he sounded great and that was that. Yesterday, my girlfriend got home and she had this glow on her face like she couldn't wait to tell me something. Apparently, she had just had a 30+ minute conversation on the phone with her brother David, and you couldn't tell that he had any sort of slurred speech or memory issues whatsoever.

So moving forward, I've planted more CBD strains. I plan on helping everyone I can that will listen. We often sound nuts (my gf and I) as we ramble on about our dog at the dog park.. ...until I bumped into somebody there last week that also takes it for her IBS. My dog BOB takes CBD daily and is a completely different boy since CBD came into his life.

David and Bob are family, I found my second calling......... great timing......

As always a special shout out and thank you to SweetSue and Intheshed for their help.

I will Continue to update this good news story...... Lord knows we could all use some.
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
Guy, you made my day. :5::5::5::5::5:

I'm on vacation, or I'd have found this sooner. This is wonderful news. And it was a balanced ratio that worked, supporting the clinical reports that the 1:1 is what the body is most often asking for.

The CBDurban, do you have any idea what the anticipated terpene profiles are?
 

Guy Cavallero

Well-Known Member
Honestly Sue, not completely sure. My girlfriend mentioned it smelled.rather sweet as I trimmed but other than that.....not really! All of the CBDurban has now been made into oil for David. He has some tests coming up this week so he is a little hesitant tocontinue taking his oil as he leads up to it....... I told him to make sure that he tells his doctor but I'm not sure that the doctor will be open to listening.
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
It’s medicine without dangerous side effects, made of molecules evolved to interlock precisely with his internal healing force. Basic biology, cannabinoids signal healing, cell by cell.

There’s no danger other than his doctor overloading him on questionable pharmaceuticals. That’s why his doctor needs to know. David doesn’t need his doctor’s permission to heal. His doctor works for him. Cannabis is a legal therapy where he lives, is that not correct?

The choice is David’s. If it were me I’d be sticking to the regimen. If he were my husband it wouldn’t even be up for discussion. I’d rather have a healing husband than a happy god-complexed doctor any day.
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
It’s been known in the medical profession since 2012 that you can positively effect Alzheimer’s with as little as one puff a day.


It’s also been known that 5 cups of coffee a day will have almost the same effect as that one puff.

A cup of coffee and a puff of cannabis. An excellent way to start the day and help keep your brain healthy. :4:
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
My pleasure Master. :5:

We’re playing with methods of micro dosing that may be useful for you.

If you create an infused oil with a small amount of THC, say one that comes in around 10mg/ml or less, you can determine how many drops from a pipette make a single ml, and then create capsules with 1 ml, 3ml, and 5ml values of THC by counting the drops.

Label carefully, and you have the perfect vehicle for micro dosing. If you need to get the values even lower you can freeze the capsules and slice them down into smaller pieces.

You want to avoid the confusion of euphoria, but tap into the benefits of wellbeing. That requires some very teeny doses in some cases.

Good luck with your father. Alzheimer’s patients have been so responsive to cannabis therapies I expect it’ll be the first-line treatment before much longer.

Cannabinoid therapies call for lots of water to wash out the waste materials. As soon as a cannabinoid signals enzymes disassemble them for waste removal, and when you have lots of inflammation you use more cannabinoids and create more waste. Keep him hydrated. :5:
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
:5::thanks::5:
Thanks again Sue. You are truly a wonderful person. I will certainly work with him to get a proper dosage as he is willing to give it a try. Of course everything is a little harder since I live in a state where it's still not legal.

Happy 4th to all!
Please keep us updated on developing the regimen and how administration goes. Detail helps enormously. :5:
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
Looks like there will be a delay (at least a month or two) on getting him started. I'll try to give you an update when I know more.
All things in their right time. :4: :love:
 

onewarmguy

Well-Known Member
Hey SweetSue, I had a meeting this afternoon with a client over a construction project (he was late), we got to talking and he said his grandfather suffered from Alzheimer's, this clicked on my own knowledge base and I mentioned the promise that CBD's are showing in retarding and sometimes reversing the progress of this nightmare illness. He immediately asked me to send him some information, he has a Phd in Pharmaceutical Sciences so his level of understanding goes WAY above mine, plus he's a really nice guy (I wouldn't be doing this otherwise). With your permission I'd like to copy/paste your transcript but I'd like to add some support for Dr. Smiths claims, do you remember if Dr. Smith cited any articles or studies I can send?
Thanks, I owe you one.
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
With your permission I'd like to copy/paste your transcript but I'd like to add some support for Dr. Smiths claims, do you remember if Dr. Smith cited any articles or studies I can send?
Thanks, I owe you one.
You have my permission to share anything I’ve written on medical cannabis. I don’t recall any articles cited by Dr. Smith, but I’m certain some exist. They’ve been using cannabis to treat Alzheimer’s for a few years now. There’s loads of data accumulating.

From a 2014 article in the Journal of Alzheimer’s Disease (vol. 42, no. 3, pp. 973-984, 2014):

The Potential Effects of THC on Alzheimer’s Disease

It shows how low-dose THC can effect the growth of toxic amyloid plagues.

And this one backing it up, titled

A molecular link between the active component of marijuana and Alzheimer's disease pathology. (Mol Pharm. 2006 Nov-Dec;3(6):773-7.)


I’m sure there’re more to be found. Good luck. :5:
 

onewarmguy

Well-Known Member
Thanks SweetSue, I tried reading "A Molecular link Between.... " LOL it left me in the dust after the first paragraph. So far over my head I couldn't see daylight. Sent it on to him anyway if he can't understand it there's no hope for any of us.
Might have to change my username to Oneconfusedguy.
 

Alafornia

Grow Journal of the Month: Dec 2019
I wish I knew then what I know now is a common refrain. My dad died from Alzheimer's and now my mom has it. She's getting CBD. I wish I could get her some THC as well, but her state doesn't allow it and circumstances prevent circumventing that limitation.

Thank you, @SweetSue for sharing the information you share. There is simply no way to place a value on it.
 

onewarmguy

Well-Known Member
It’s been known in the medical profession since 2012 that you can positively effect Alzheimer’s with as little as one puff a day.


It’s also been known that 5 cups of coffee a day will have almost the same effect as that one puff.

A cup of coffee and a puff of cannabis. An excellent way to start the day and help keep your brain healthy. :4:
It's been known for much longer than that, the publication dates of some of the studies I've recently seen on the effect of CBD/THC on Alzheimer's go as far back as 1998. It's that damned Schedule 1 classification that's suffocated any widespread distribution of research results.

I have one question for consideration, if we already have cannabinoid receptors in our brains why and how did we develop them? It strikes me that evolution is a very efficient process and in general only beneficial mutations survive in our gene pool. If that's the case, it seems like the benefits of the noble herb may have been recognized by our DNA a few hundred thousand years ago, otherwise why did we develop the receptors?
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
It's been known for much longer than that, the publication dates of some of the studies I've recently seen on the effect of CBD/THC on Alzheimer's go as far back as 1998. It's that damned Schedule 1 classification that's suffocated any widespread distribution of research results.

I have one question for consideration, if we already have cannabinoid receptors in our brains why and how did we develop them? It strikes me that evolution is a very efficient process and in general only beneficial mutations survive in our gene pool. If that's the case, it seems like the benefits of the noble herb may have been recognized by our DNA a few hundred thousand years ago, otherwise why did we develop the receptors?
The receptors are for the endocannabinoids your body produces. It was the discovery that THC activates a receptor and the realization that this implied something the body produced was intended to activate this receptor system that led to the discovery of our homeostatic ECS.

We’ve known about anandamide and 2-AG for decades, and the pharmaceutical industry has worked furiously and fruitlessly to come up with synthetic molecules that would allow them to say, “We don’t need cannabis” the way they decided we didn’t need willow bark, or any of the other holistic modalities that help an ailing body heal.

We evolved to spontaneously heal, cell by cell, all across the body systems, and the endocannabinoid system monitors all of those systems and keeps them in balance using those receptors. It’s pure serendipity that cannabis can so efficiently mimic what our endocannabinoids do.
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
I wish I knew then what I know now is a common refrain. My dad died from Alzheimer's and now my mom has it. She's getting CBD. I wish I could get her some THC as well, but her state doesn't allow it and circumstances prevent circumventing that limitation.

Thank you, @SweetSue for sharing the information you share. There is simply no way to place a value on it.
My heart goes out to you. :5: I’m newly moved into a retirement community in a non-legal state. There are neighbors here I’ve already grown to love falling into the abyss of Alzheimer’s, and I’m standing here, helpless to do anything more than offer CBD guidance.

A daily dose of 5mg of THC coupled with 5 mg of CBD and it’s possible the disease could be stopped in its tracks. It feels criminal, doesn’t it?

We’re not here to save the world or heal anyone. The goal is to share the knowledge as widely as possible and keep anticipating better outcomes than what we’re looking at. I plan to believe this madness is close to an end, and that’s the energy I’ll stubbornly hold to as we continue to spread the word that Alzheimer’s doesn’t have to be the dark hole our government has let it become.

I think if there are answers to be found they won’t be coming in on the frequency of frustration. :laugh2: I’ll keep wearing my rosy-colored glasses and anticipating positive change :4:
 
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