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An endogenous Cannabinoid (2-AG) Is Neuroprotective After Brain Injury

Julie Gardener

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An endogenous Cannabinoid (2-AG) Is Neuroprotective After Brain Injury.​
Panikashvili D, Simeonidou C, Ben-Shabat S, Hanus L, Breuer A, Mechoulam R, Shohami E.
Department of Pharmacology, Medical Faculty, Hebrew University, Jerusalem 91120, Israel.

Nature. 2001 Oct 4;413(6855):527-31.


Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary damage. Protective mechanisms to attenuate damage are also set in motion. 2-Arachidonoyl glycerol (2-AG) is an endogenous cannabinoid, identified both in the periphery and in the brain, but its physiological roles have been only partially clarified. Here we show that, after injury to the mouse brain, 2-AG may have a neuroprotective role in which the cannabinoid system is involved. After closed head injury (CHI) in mice, the level of endogenous 2-AG was significantly elevated. We administered synthetic 2-AG to mice after CHI and found significant reduction of brain oedema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared with controls. When 2-AG was administered together with additional inactive 2-acyl-glycerols that are normally present in the brain, functional recovery was significantly enhanced. The beneficial effect of 2-AG was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor.

PMID: 11586361 [PubMed - indexed for MEDLINE]

Source: An endogenous cannabinoid (2-AG) is neuroprotectiv... [Nature. 2001] - PubMed result
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