420 Magazine Background

Beneficial And Adverse Effects Of Cannabidiol In A Parkinson Patient With Sinemet

Truth Seeker

New Member
In idiopathic dystonia, the terapeutic effect of marijuana smoking is reported to be comparable to diazepam (C.D. Marsden, in Disorders of Movement, 1981,81). The non-psychoactive cannabis derivative, cannabidiol (CBD), also improves dystonia (Consroe and Snider, in Cannbinoids as Therapeutic Agents, in press). We report the effect of CBD on dystonia secondary to Sinemet in parkinsonism, a disorder thought to be a relative contraindication for cannabinoids (D.Moss et al, Pharmacol Biochem Behav 1981, 1984). The patient, a 42-year- old man with an 8-year history of parkinsonism, developed peak-dose dyskinesia about 4 years ago and action dystonia affecting all limbs more recently. Trihexyphenidyl and bromocriptine each produced only slight improvement. To stable optimal dosages of the three drugs, CBD was added, starting with 100 mg/d and increasing by 100 mg weekly. At 100 to 200 mg/d, there was a decrease in clinical fluctuations and in dyskinesia scores (by 30%) without a significant worsening of the parkinsonism. At 300 to 400 mg/d, there was no further improvement in the dyskinesia, and adverse effects (dizziness, drowsiness, increased Parkinson symptoms) appeared. CBD withdrawal resulted in 3 days of severe generalized dystonia and several weeks of increased sensitivity to Sinemet, suggestive of a "drug holiday" effect.

Source: Clinical Studies and Case Reports


Well-Known Member
So I'm horrible with 'Dr. Speak'. If I read this right, the CBD treatments only showed mild improvement and then reverted to a withdrawal-like symptom? I'm sorry, but I just keep going round and round and round trying to make heads or tails of all this. I'm looking for the definitive answer. Do CBDs slow? stop? aid? people with the onset of Parkinsons?
Everything I find on this is written for people with far larger brains than mine. I need to find the "CBDs Fo Dummies" forum. Any clues where to look? I see this is a waaaay old post. Hope you're still about to give directions......

Thanks!! Andy.
Top Bottom