Jacob Bell
New Member
In a mouse model for inflammatory bowel disease cannabinoids reduced inflammation and diarrhoea. Mice received oil of mustard that caused a severe colitis. Both a CB1 receptor agonist and a CB2 receptor agonist reduced colon shrinkage, colon inflammation, and diarrhoea, with the CB1 receptor agonist being somewhat more effective.
There were more CB1 receptors in nerve cells of the large intestine if the bowel was inflamed compared to healthy bowels. There were also more CB1 receptors in the inner wall (endothelium) of the large intestine compared to non-inflamed tissue. There was a high number of CB2 receptors in immune cells that infiltrated the inflamed tissue. Authors note that the demonstration of CB1 receptor effects "reinforce the importance of neuronal activation in intestinal inflammation."
(Source: Kimball ES, Schneider CR, Wallace NH, Hornby PJ. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Am J Physiol Gastrointest Liver Physiol 2006 Mar 30; [electronic publication ahead of print])
Source: Cannabinoids Reduce Inflammation of the Bowel in Animal Model
There were more CB1 receptors in nerve cells of the large intestine if the bowel was inflamed compared to healthy bowels. There were also more CB1 receptors in the inner wall (endothelium) of the large intestine compared to non-inflamed tissue. There was a high number of CB2 receptors in immune cells that infiltrated the inflamed tissue. Authors note that the demonstration of CB1 receptor effects "reinforce the importance of neuronal activation in intestinal inflammation."
(Source: Kimball ES, Schneider CR, Wallace NH, Hornby PJ. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Am J Physiol Gastrointest Liver Physiol 2006 Mar 30; [electronic publication ahead of print])
Source: Cannabinoids Reduce Inflammation of the Bowel in Animal Model
