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Circulating Endocannabinoid Concentrations During Orthostatic Stress

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BACKGROUND:
In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition.

MATERIALS AND METHODS:
We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope.

RESULTS:
With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged.

CONCLUSIONS:
In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.

Source: Circulating endocannabinoid concentrations du... [Clin Auton Res. 2009] - PubMed - NCBI
 
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