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Drying plant leaves: Serious problem

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My plant leaves seem to be drying up and dying in random locations. I am in week 4. This grown in an indoor grow tent. My ppm level is about 320, and my ph is about 5.9. It is grown under a 450 watt led light. I thought maybe it was light burn, so I moved the light from 12in away to about 18in away. However, the problem is persisting. The temperature is a bit low at 65 degrees, and I am unsure of the humidity levels.