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Lack Of Tolerance To 9 -Tetrahydrocannabinol In Chimpanzees

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Five chimpanzees were given Delta(9)-tetrahydrocannabinol (Delta(9)THC): 1.0 milligram per kilogram of body weight for 21 days and 4.0 milligrams per kilogram of body weight for 42 days. Although accuracy and speed of performance on a delayed matching-to-sample task were significantly affected by both doses, tolerance to Delta(9)THC did not develop. No long-term behavioral effects of Delta(9)THC were observed after termination of the drug regimens.

Source: Lack of tolerance to 9 -tetrahydrocannabinol in chim... [Science. 1973] - PubMed - NCBI
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