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I pruned when I had a powdery mildew issue. I got rid of the affected leaves and thinned a little bit to create some additional airflow.

You want to prune gently. As another poster eluded to, I would be cautious about pruning during mid to late flower.

When you prune, the plant puts some energy into repair. That can affect growth in veg and bud development in flower.

So from what I've been able to gather, prune lightly and not in the mid to later stage of flower.

That's how I prefer it. There are many other ideas about pruning out there. This is mine..

Hope it helps.

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