Jacob Bell
New Member
Author(s) Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG
Journal, Volume, Issue Pharmacol Biochem Behav. 1991 Nov;40(3):695-700.
Major outcome(s) Significant weight gain
Indication Appetite loss/weight loss;HIV/AIDS
Medication Delta-9-THC
Route(s) Oral
Dose(s) THC 2x2.5 mg for 5 months
Duration (days)
Participants 10 patients with AIDS
Design Open study
Type of publication Medical journal
Address of author(s) UNIMED, Inc., Somerville, NJ 08876
Abstract
Dronabinol, delta-9-tetrahydrocannabinol in sesame oil, has been used for several years as an antiemetic for patients receiving cancer chemotherapy. In combination studies with prochlorperazine, enhancement of efficacy, as measured by duration of episodes of nausea and vomiting and by severity of nausea, has been found. The incidence of psychotropic effects from dronabinol appears to be decreased by concomitant administration of prochlorperazine. In open pilot studies, dronabinol caused weight gain in seven of ten patients with symptomatic HIV infection. In both HIV and cancer patients, dronabinol improved appetite at a dose which was well tolerated for chronic administration.
Source: Recent Clinical Experience With Dronabinol
Journal, Volume, Issue Pharmacol Biochem Behav. 1991 Nov;40(3):695-700.
Major outcome(s) Significant weight gain
Indication Appetite loss/weight loss;HIV/AIDS
Medication Delta-9-THC
Route(s) Oral
Dose(s) THC 2x2.5 mg for 5 months
Duration (days)
Participants 10 patients with AIDS
Design Open study
Type of publication Medical journal
Address of author(s) UNIMED, Inc., Somerville, NJ 08876
Abstract
Dronabinol, delta-9-tetrahydrocannabinol in sesame oil, has been used for several years as an antiemetic for patients receiving cancer chemotherapy. In combination studies with prochlorperazine, enhancement of efficacy, as measured by duration of episodes of nausea and vomiting and by severity of nausea, has been found. The incidence of psychotropic effects from dronabinol appears to be decreased by concomitant administration of prochlorperazine. In open pilot studies, dronabinol caused weight gain in seven of ten patients with symptomatic HIV infection. In both HIV and cancer patients, dronabinol improved appetite at a dose which was well tolerated for chronic administration.
Source: Recent Clinical Experience With Dronabinol
