Science/Germany: Clinical Study On THC In Tourette's Syndrome

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At the Medical School of Hanover another study on the efficacy of THC in TOURETTE's syndrome has started at the end of April under the guidance of Dr. Kirsten Mueller-Vahl. Until now 15 patients have been included in the study.

A total of 24 patients with TOURETTE's syndrome shall be treated over a period of 6 weeks. 12 patients will randomly receive THC (Marinol), the other 12 placebo capsules, without knowing which substance they get.

It is the aim of the study to examine the effects of THC on different symptoms of TOURETTE's syndrome (tics, obsessive compulsive behaviour, anxiety, depression) and to measure possible side effects on brain function (attention, memory, concentration, reaction time). Termination of the study is intended to be in November 2000. Dosing starts with 2.5 mg daily, than every three days increase by 2.5 mg until a maximum of 10 mg. There is the possibility of individual dose adjustment between 2.5, 5, 7.5, and 10 mg per day. Dosing is once daily during breakfast or lunch.

The actual study is a follow-up of a pilot study carried out last year, that had shown that a one-time application of THC led to a significant decrease in tics and obsessive behaviour in 12 patients.

Source: International Association for Cannabis as Medicine