The Nonpsychoactive Cannabis Constituent Cannabidiol is a Wake-Inducing Agent

Jacob Bell

New Member
Author(s) Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, Mechoulam R, Drucker-Colín R
Institution Laboratorio de Neurobiologia, Facultad de Medicina, Universidad Autonoma de Campeche.
Source Behav Neurosci 2008 Dec; 122(6):1378-82.
Abstract Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors' group. Here, the authors report that when administered 10 or 20 microg/1 microl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN. (PsycINFO Database Record (c) 2008 APA, all rights reserved).
Language eng
Pub Type(s) Journal Article
PubMed ID 19045957


Source: The nonpsychoactive cannabis constituent cannabidiol is a wake-inducing agent
 
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