Study Shows Medical Marijuana Appears To Be Safe

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MAILMASTER Tweed Marijuana production assistant Adam Morris tends to plants at the company green house in Smiths Falls, Ontario, Canada, March 19, 2014. With a sweeping new policy for medical marijuana, Canada is aiming for a market of large-scale — and highly regulated — growers. (Dave Chan/The New York Times) -- PHOTO MOVED IN ADVANCE AND NOT FOR USE - ONLINE OR IN PRINT - BEFORE MAY 25, 2014. Subject: New York Times photos to go with Smith Falls marijuana feature On 2014-05-26, at 11:25 AM, Cudmore, Doug wrote: New York Times photos to go with Smith Falls marijuana feature Douglas Cudmore Business Editor The Toronto Star CANADA_MARIJUANA_MARKET_ADV25_6_1146871.JPG CANADA_MARIJUANA_MARKET_ADV25_1_1146866.JPG CANADA_MARIJUANA_MARKET_ADV25_2_1146867.JPG CANADA_MARIJUANA_MARKET_ADV25_3_1146868.JPG CANADA_MARIJUANA_MARKET_ADV25_4_1146869.JPG CANADA_MARIJUANA_MARKET_ADV25_5_1146870.JPG

A Canadian research team has completed a benchmark study that looks at the effects of cannabis when used in pain management.

The team led by Dr. Mark Ware from the Research Institute of the McGill University Health Centre (RI-MUHC) in Montréal has completed a national multicentre study looking at the safety of medical cannabis use among patients suffering from chronic pain.

They found that patients with chronic pain who used cannabis daily for one year, when carefully monitored, did not have an increase in serious adverse events compared to pain patients who did not use cannabis. The results, which have been published online in The Journal of Pain, will serve as a benchmark study on the side effects of cannabis when used in pain management.

“This is the first and largest study of the long term safety of medical cannabis use by patients suffering from chronic pain ever conducted,” says lead author, Dr. Ware, pain specialist at the Montreal General Hospital of the MUHC and associate professor in Family Medicine and Anesthesia at McGill University. “We found that medical cannabis, when used by patients who are experienced users, and as part of a monitored treatment program for chronic pain over one year, appears to have a reasonable safety profile.”

“This is the first and largest study of the long term safety of medical cannabis use by patients suffering from chronic pain ever conducted,” says lead author, Dr. Ware, pain specialist at the Montreal General Hospital of the MUHC and associate professor in Family Medicine and Anesthesia at McGill University. “We found that medical cannabis, when used by patients who are experienced users, and as part of a monitored treatment program for chronic pain over one year, appears to have a reasonable safety profile.”

As part of the Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS), that started in 2004, the researchers followed 215 adult patients, with chronic non-cancer pain, who used medical cannabis, and compared them to a control group of 216 chronic pain sufferers who were not cannabis users. The study involved seven clinical centres with pain management expertise across Canada located in Fredericton, Halifax, London, Montreal, Toronto and Vancouver.

The cannabis users were given access to herbal cannabis containing 12.5 per cent THC from a licensed cannabis producer. Cannabis was dispensed through the hospital pharmacy at each site, and patients collected their supply every month after completing the necessary visits and tests. Along with information on adverse effects, subjects underwent lung function and cognitive testing, and were asked about their pain, mood and quality of life over the one year of follow up. A number of the subjects underwent complete panels of blood tests for routine biochemistry, liver and kidney function, and selected hormone levels. The average amount of cannabis used overall was 2.5 grams per day whether smoked, vaporized or taken as edibles.

“Our data show that daily cannabis users had no greater risk than non-users (control group) to experience serious adverse events,’’ explains Dr. Aline Boulanger, director of the pain clinic at the Centre hospitalier de l’Université de Montréal. ‘’We found no evidence of harmful effects on cognitive function, or blood tests among cannabis consumers and we observed a significant improvement in their levels of pain, symptom distress, mood and quality of life compared to controls. ’’

However, the researchers did report an increased risk of non-serious adverse events in medical cannabis consumers such as headache, nausea, dizziness, somnolence, and respiratory problems associated with smoking.
“It is important to note the limitations of the study,” adds Dr. Ware. “Patients were self-selected, not randomized, and most were experienced users. So what we are seeing is that it appears to be a relatively safe drug when used by people who have already determined that it helps them. We cannot draw conclusions about safety issues of new cannabis users”.

News Moderator: Jacob Redmond 420 MAGAZINE ®
Full Article: Medical marijuana appears to be safe, study shows
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Photo Credit: Alessandro Bianchi/Reuters
Website: Canada Journal

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