Jacob Bell
New Member
Leo E. Hollister, Saul L. Kanter
Veterans Administration Hospital, Palo Alto, California 94304 U.S.A.
Received 11 April 1979; Available online 9 March 2004.
Abstract
For various experimental studies it is often desirable to classify categories of cannabis use. For instance, in a study of the kinetics of δ-9-tetrahydrocannabinol (THC) in man, we wanted to see if there were differences between "heavy" and "light" users of the drug. "Heavy" use was defined as once daily or more, while "light" use was defined as sporadic or occasional, no more frequent than once monthly.
Previously, we had found that the 11-oic acid of THC was not only the major metabolite to appear in the urine but also that its appearance in urine was prompt and lasted for at least 72 hours after a single exposure [1]. We decided to use the presence of this material in urine as a marker for heavy and light use; one would expect to find it regularly in heavy users and rarely, if at all, among light users. All subjects entering the study declared their pattern of use and then were asked to provide a spontaneously voided urine, to be used for analysis of THC-11-oic acid.
Source: Laboratory Verification Of "Heavy" And "Light" Users Of Cannabis
Veterans Administration Hospital, Palo Alto, California 94304 U.S.A.
Received 11 April 1979; Available online 9 March 2004.
Abstract
For various experimental studies it is often desirable to classify categories of cannabis use. For instance, in a study of the kinetics of δ-9-tetrahydrocannabinol (THC) in man, we wanted to see if there were differences between "heavy" and "light" users of the drug. "Heavy" use was defined as once daily or more, while "light" use was defined as sporadic or occasional, no more frequent than once monthly.
Previously, we had found that the 11-oic acid of THC was not only the major metabolite to appear in the urine but also that its appearance in urine was prompt and lasted for at least 72 hours after a single exposure [1]. We decided to use the presence of this material in urine as a marker for heavy and light use; one would expect to find it regularly in heavy users and rarely, if at all, among light users. All subjects entering the study declared their pattern of use and then were asked to provide a spontaneously voided urine, to be used for analysis of THC-11-oic acid.
Source: Laboratory Verification Of "Heavy" And "Light" Users Of Cannabis
