Jacob Bell
New Member
Linda C. Hodges∗, Howard M. Deutsch" , Keith Green"¡, Leon H. Zalkow"
Purchase
∗ Department of Chemistry, Kennesaw College, Marietta, Georgia 30061, USA
" School of Chemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
"¡ Department of Ophthalmology and Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
Received 9 October 1984; Available online 5 May 2003.
Abstract
Aqueous extraction of air dried Cannabis sativa (marijuana) yields, after dialysis, a mixture of high molecular weight carbohydrate-containing components. This mixture has very potent intraocular pressure-lowering activity (antiglaucoma) when tested by intravenous injection into rabbits. Partial purification by DEAE-cellulose and gel filtration chromatography has yielded very active material (lowers intraocular pressure maximally at 1 μg/animal) with an estimated molecular weight of about 500 000. The active material contains mostly carbohydrate with a small amount of protein. Rhamnose, galactose and uronic acid are the major sugar constituents. The composition of components suggests that the active material is a pectic polysaccharide possibly derived from the cell wall.
Source: Polysaccharides from Cannabis sativa active in lowering intraocular pressure
Purchase
∗ Department of Chemistry, Kennesaw College, Marietta, Georgia 30061, USA
" School of Chemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
"¡ Department of Ophthalmology and Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
Received 9 October 1984; Available online 5 May 2003.
Abstract
Aqueous extraction of air dried Cannabis sativa (marijuana) yields, after dialysis, a mixture of high molecular weight carbohydrate-containing components. This mixture has very potent intraocular pressure-lowering activity (antiglaucoma) when tested by intravenous injection into rabbits. Partial purification by DEAE-cellulose and gel filtration chromatography has yielded very active material (lowers intraocular pressure maximally at 1 μg/animal) with an estimated molecular weight of about 500 000. The active material contains mostly carbohydrate with a small amount of protein. Rhamnose, galactose and uronic acid are the major sugar constituents. The composition of components suggests that the active material is a pectic polysaccharide possibly derived from the cell wall.
Source: Polysaccharides from Cannabis sativa active in lowering intraocular pressure
