Julie Gardener
New Member
Cannabinoids In The Treatment Of Cancer
Amy Alexandera, Paul F. Smitha and Rhonda J. RosengrenDepartment of Pharmacology and Toxicology, University of Otago, Dunedin 9001, New Zealand
Received 21 January 2009; revised 3 April 2009; accepted 3 April 2009.
Abstract
Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB1 and CB2) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results.
Source: ScienceDirect - Cancer Letters : Cannabinoids in the treatment of cancer
