Jacob Bell
New Member
Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo
Author(s) Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA
Journal, Volume, Issue Veterinary and Human Toxicology 1979;21:338-340
Major outcome(s) dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently)
Indication Nausea/vomiting;Cancer;Cancer chemotherapy
Medication Delta-9-THC
Route(s) Oral
Dose(s) 10 mg/m2 every 4 h, 3 doses a day
Duration (days) on day 1 and day 8 of chemotherapy
Participants patients receiving MOPP chemotherapy
Design Controlled study
Abstract
Summary
A double-blind cross-over trial with delta-9-tetrahydrocannabinol (THC) and placebo was employed to test the antiemetic effect on nausea and vomiting after MOPP-therapy. Although THC had remarkable antiemetic effects, there side effects were severe. Most patients preferred the nausea and the vomiting after MOPP-therapy to the use of THC. A relation between the antiemetic action or the side-effects and the blood-level of THC could not be demonstrated.
Source: Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo
Author(s) Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA
Journal, Volume, Issue Veterinary and Human Toxicology 1979;21:338-340
Major outcome(s) dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently)
Indication Nausea/vomiting;Cancer;Cancer chemotherapy
Medication Delta-9-THC
Route(s) Oral
Dose(s) 10 mg/m2 every 4 h, 3 doses a day
Duration (days) on day 1 and day 8 of chemotherapy
Participants patients receiving MOPP chemotherapy
Design Controlled study
Abstract
Summary
A double-blind cross-over trial with delta-9-tetrahydrocannabinol (THC) and placebo was employed to test the antiemetic effect on nausea and vomiting after MOPP-therapy. Although THC had remarkable antiemetic effects, there side effects were severe. Most patients preferred the nausea and the vomiting after MOPP-therapy to the use of THC. A relation between the antiemetic action or the side-effects and the blood-level of THC could not be demonstrated.
Source: Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo
