Jacob Bell
New Member
Urinary toxicological screening: analytical interference between niflumic acid and cannabis
Author(s) Boucher A, Vilette P, Crassard N, Bernard N, Descotes J
Institution Centre d'évaluation et d'information sur la pharmacodépendance (CEIP), 162 avenue Lacassagne, Lyon cedex 03, France.
Source Arch Pediatr 2009 Nov; 16(11):1457-60.
MeSH Administration, Rectal
Anti-Inflammatory Agents, Non-Steroidal
Cannabinoids
Child Behavior Disorders
Child, Preschool
Drug Interactions
False Positive Reactions
Female
Humans
Niflumic Acid
Substance Abuse Detection
Abstract One case of analytical interference between cannabis and niflumic acid resulting in a false-positive screening in a 3-year-old girl is described.
CASE REPORT: The child was hospitalized because of behavioral disturbances of unknown origin. The only noteworthy finding in her medical history was a drug treatment including suppositories of niflumic acid, started 5 days before. The initial urinary toxicological screening was positive for cannabinoids, but the child's parents strongly denied the exposure. Another analysis was performed by the same laboratory on the same urine sample using chromatography and confirmed the absence of any cannabinoids, while clearly identifying the presence of niflumic acid. COMMENTS: Immunoanalysis for toxicological analysis has various limitations that must be known. False-positive results of the urinary screening for cannabis in patients treated with niflumic acid are well recognized although seldom reported. All usual screening tests are not concerned by this ill-explained interference with niflumic acid and all formulations can be involved except transcutaneous formulations. Because of the wide use of this nonsteroidal anti-inflammatory drug, particularly in pediatric patients, it is important to know that this type of interference can occur with various screening tests for cannabis so that misleading conclusions can be avoided.
Language fre
Pub Type(s) Case Reports
English Abstract
Journal Article
PubMed ID 19716686
Source: Urinary toxicological screening: analytical interference between niflumic acid and cannabis
Author(s) Boucher A, Vilette P, Crassard N, Bernard N, Descotes J
Institution Centre d'évaluation et d'information sur la pharmacodépendance (CEIP), 162 avenue Lacassagne, Lyon cedex 03, France.
Source Arch Pediatr 2009 Nov; 16(11):1457-60.
MeSH Administration, Rectal
Anti-Inflammatory Agents, Non-Steroidal
Cannabinoids
Child Behavior Disorders
Child, Preschool
Drug Interactions
False Positive Reactions
Female
Humans
Niflumic Acid
Substance Abuse Detection
Abstract One case of analytical interference between cannabis and niflumic acid resulting in a false-positive screening in a 3-year-old girl is described.
CASE REPORT: The child was hospitalized because of behavioral disturbances of unknown origin. The only noteworthy finding in her medical history was a drug treatment including suppositories of niflumic acid, started 5 days before. The initial urinary toxicological screening was positive for cannabinoids, but the child's parents strongly denied the exposure. Another analysis was performed by the same laboratory on the same urine sample using chromatography and confirmed the absence of any cannabinoids, while clearly identifying the presence of niflumic acid. COMMENTS: Immunoanalysis for toxicological analysis has various limitations that must be known. False-positive results of the urinary screening for cannabis in patients treated with niflumic acid are well recognized although seldom reported. All usual screening tests are not concerned by this ill-explained interference with niflumic acid and all formulations can be involved except transcutaneous formulations. Because of the wide use of this nonsteroidal anti-inflammatory drug, particularly in pediatric patients, it is important to know that this type of interference can occur with various screening tests for cannabis so that misleading conclusions can be avoided.
Language fre
Pub Type(s) Case Reports
English Abstract
Journal Article
PubMed ID 19716686
Source: Urinary toxicological screening: analytical interference between niflumic acid and cannabis
