Jacob Bell
New Member
Author(s) Plange N, Arend KO, Kaup M, Doehmen B, Adams H, Hendricks S, Cordes A, Huth J, Sponsel WE, Remky A.
Journal, Volume, Issue Am J Ophthalmol. 2007 Jan;143(1):173-4.
Major outcome(s) THC reduced intraoculat pressure and improved blood circulation in the retina.
Indication Glaucoma
Medication Delta-9-THC
Route(s) Oral
Dose(s) 7.5 mg
Duration (days) 1
Participants 8 healthy subjects
Design Open study
Type of publication Medical journal
Address of author(s) RWTH Aachen University, Department of Ophthalmology, Aachen, Germany.
Abstract
PURPOSE: To investigate the effects of oral cannabinoids on retinal hemodynamics assessed by video fluorescein angiography in healthy subjects. DESIGN: Interventional study. METHODS: In a self-experiment, the cannabinoid dronabinol (delta-9-tetrahydrocannabinol [THC]) was administered orally to eight healthy medical doctors (7.5 mg Marinol; Unimed Pharmaceuticals, Chicago, Illinois, USA). At baseline and two hours after dronabinol intake, intraocular pressure (IOP) was measured and retinal hemodynamics were assessed by fluorescein angiography. The retinal arteriovenous passage time was determined on the basis of dye dilution curves by means of digital image analysis in a masked fashion. RESULTS: Dronabinol resulted in a significant IOP reduction from 13.2 +/- 1.9 mm Hg to 11.8 +/- 2.0 mm Hg (P = .038). The retinal arteriovenous passage time decreased from 1.77 +/- 0.35 seconds to 1.57 +/- 0.31 seconds (P = .028). Systemic blood pressure and heart rate were not statistically significantly altered. CONCLUSIONS: Cannabinoids, already known for their ability to reduce IOP, may result in increased retinal hemodynamics. This may be beneficial in ocular circulatory disorders, including glaucoma.
Source: Dronabinol And Retinal Hemodynamics In Humans
Journal, Volume, Issue Am J Ophthalmol. 2007 Jan;143(1):173-4.
Major outcome(s) THC reduced intraoculat pressure and improved blood circulation in the retina.
Indication Glaucoma
Medication Delta-9-THC
Route(s) Oral
Dose(s) 7.5 mg
Duration (days) 1
Participants 8 healthy subjects
Design Open study
Type of publication Medical journal
Address of author(s) RWTH Aachen University, Department of Ophthalmology, Aachen, Germany.
Abstract
PURPOSE: To investigate the effects of oral cannabinoids on retinal hemodynamics assessed by video fluorescein angiography in healthy subjects. DESIGN: Interventional study. METHODS: In a self-experiment, the cannabinoid dronabinol (delta-9-tetrahydrocannabinol [THC]) was administered orally to eight healthy medical doctors (7.5 mg Marinol; Unimed Pharmaceuticals, Chicago, Illinois, USA). At baseline and two hours after dronabinol intake, intraocular pressure (IOP) was measured and retinal hemodynamics were assessed by fluorescein angiography. The retinal arteriovenous passage time was determined on the basis of dye dilution curves by means of digital image analysis in a masked fashion. RESULTS: Dronabinol resulted in a significant IOP reduction from 13.2 +/- 1.9 mm Hg to 11.8 +/- 2.0 mm Hg (P = .038). The retinal arteriovenous passage time decreased from 1.77 +/- 0.35 seconds to 1.57 +/- 0.31 seconds (P = .028). Systemic blood pressure and heart rate were not statistically significantly altered. CONCLUSIONS: Cannabinoids, already known for their ability to reduce IOP, may result in increased retinal hemodynamics. This may be beneficial in ocular circulatory disorders, including glaucoma.
Source: Dronabinol And Retinal Hemodynamics In Humans
