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Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.
Source: Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. - Medical Journals - Healia
Source: Overeating, Alcohol and Sucrose Consumption Decrease in Cb1 Receptor Deleted Mice. - Medical Journals - Healia
