Activation of Cannabinoid Receptors; Ischemic Myocardial Necrosis

Jacob Bell

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Ugdyzhekova DS, Krylatov AV, Bernatskaya NA, Maslov LN, Mechoulam R, Pertwee RG.

Tomsk State Pedagogical University.


We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

Source: Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis
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