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Amelioration of Cancer Chemotherapy-Induced Nausea and Vomiting

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Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol


Author(s) Ekert H, Waters KD, Jurk IH, Mobilia J, Loughnan P
Journal, Volume, Issue Med J Aust. 1979 Dec 15;2(12):657-9.
Major outcome(s) THC was effective in reducing nausea and vomiting but not in all patients
Indication Nausea/vomiting
Medication Delta-9-THC
Route(s) Oral
Dose(s) 10 mg/m2 2 hr prior to chemo and 4, 8, 16 and 24 h after the first dose;
Duration (days)
Participants Children receiving cancer chemotherapy
Design Controlled study
Type of publication Medical journal


Abstract

The antinausea and antivomiting effects of delta-9-tetrahydrocannabinol (THC) in children receiving cancer chemotherapy were compared with those of metoclopramide syrup and prochlorperazine tablets in two double-blind studies. THC was found to be a significantly better antinausea and antivomiting agent, but not all patients obtained relief of nausea and vomiting with THC. In some patients, THC enhanced appetite during a course of chemotherapy. In two patients, a "high" associated with THC administrationwas reported. Drowsiness was reported significantly more frequently with THC.


Source: Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol
 
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