Cannabinoid Receptor Function Is Altered By Nutrionally Deficient Diet

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Cannabinoid researchers at Temple University gathered for their bimonthly meeting discussion on the endocannabinoid system.Megan Trznadel lead the discussion on a recently published article on nutrition and endocannabinoids. Ms.Trznadel is an undergraduate in Temple's Neuroscience program, she is currently studying the cannabinoid type 1 receptor in the laboratory of Dr. Mary Abood.

The presentation showed new data that suggests our diet can affect the response to cannabinoids. The authors demonstrate, in rats, that an Omega-3 deficient diet leads to a less functional endocannabinoid system, specifically by reducing the functionality of the Cannabinoid type 1 receptor (CB1R). The reduction of CB1Rs was associated with impaired emotional behavior by the authors. Additionally, this article discusses the lack of essential nutrients in western diets.

View slideshow: Omega-3 Research Figures
In the United State inexpensive, high calorie, high fat, nutritionally deficient diets are common. These bad diets are correlated to obesity and brain disease. For example, an imbalance in Omega-3 fatty acids has been linked to nueropsychiatric diseases, like depression. However the mechanism of neuroprotection from Omega-3 fatty acids remains unknown.

The endocannabinoid system may require a diet rich in Omega-3 fatty acids (i.e. Fish, nuts,etc). Our diet can influence our response to cannabinoids and Cannabis. Could the negative effects of cannabinoids be related to nutrionally-deficient diets, which are also associated with mental diseases, such as depression? This study raises a number of radical ideas that warrant further studies.

Source: Cannabinoid Receptor Function is Altered by Nutrionally Deficient Diet - Philadelphia medical marijuana |
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