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Is GPR55 An Anandamide Receptor?

Julie Gardener

New Member
Is GPR55 An Anandamide Receptor?
Brown AJ, Robin Hiley C.
Department of Screening and Compound Profiling, Molecular Discovery Research, GlaxoSmithKline, New Frontiers Science Park, GlaxoSmithKline, Essex, UK.

Vitam Horm. 2009;81:111-37.


Anandamide activates CB(1) cannabinoid receptors but also has effects, particularly in the vasculature, that cannot be explained by actions at either this or the other cloned cannabinoid receptor, the CB(2) receptor. These effects are probably mediated by a novel G protein-coupled receptor, but genome searching has not revealed a strong candidate. Several approaches have suggested that an orphan receptor, GPR55, is a target for anandamide, but the pharmacology of this receptor is such that it cannot be categorically identified as a cannabinoid receptor. GPR55 appears primarily to be a receptor for lysophosphatidylinositol which may exhibit biased agonism, leading to it also responding to anandamide. GPR55 activates G(alpha12) and G(alpha13) and thence RhoA, leading to an oscillatory intracellular Ca(2+) signal. Further complexity arises from possible interactions between the anandamide-sensitive CB(1) receptor and GPR55. Overall, it appears that GPR55 has several signaling modalities and that, while anandamide can activate systems containing this receptor, GPR55 cannot yet be primarily designated a receptor for this endocannabinoid.

PMID: 19647110 [PubMed - indexed for MEDLINE]

Source: Is GPR55 an anandamide receptor? [Vitam Horm. 2009] - PubMed result

Sister Vee

New Member
Very good question...in the old days we used to refer to the EC System as The THC Receptor System...reason being ONLY THC and ONLY THC actually binds with the cloned CB 1 and 2...other Cannabinoids do interact and can even bind to other receptors like dopamine receptors, CBD does bind with it, for example...but yea only THC actually binds to the Cannabinoid Receptors so ii still believe that there is a lot of truth to your question since Anandamide is our natural THC as 2AG is our natural CBD...blessed be
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