Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.Ugdyzhekova DS, Davydova YG, Maimeskulova LA, Mechoulam R.
Tomsk State Pedagogical University, Russia.
Bull Exp Biol Med. 2000 Nov;130(11):1087-9.
Intravenous injection of the selective cannabinoid receptor agonist HU-210 in doses of 0.05 and 0.25 mg/kg increased heart resistance to arrhythmogenic effects of epinephrine, while intracerebroventricular infusion of this substance had no effect on the incidence of epinephrine-induced arrhythmia. The selective antagonist of type I cannabinoid receptors SR141716A in a dose of 3 mg/kg and ganglion blocker hexamethonium in a dose of 10 mg/kg did not modify the antiarrhythmic effect of HU-210. This effect of HU-210 is probably related to activation of type II peripheral cannabinoid receptors.
PMID: 11182823 [PubMed - indexed for MEDLINE]
Source: Involvement of central and peripheral cannabinoid ... [Bull Exp Biol Med. 2000] - PubMed result