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cannabinoid 'eceptors in the Regulation of Heart Resistance to Arrhythmogenic Effects

Julie Gardener

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Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.​
Ugdyzhekova DS, Davydova YG, Maimeskulova LA, Mechoulam R.
Source
Tomsk State Pedagogical University, Russia.

Bull Exp Biol Med. 2000 Nov;130(11):1087-9.


Abstract

Intravenous injection of the selective cannabinoid receptor agonist HU-210 in doses of 0.05 and 0.25 mg/kg increased heart resistance to arrhythmogenic effects of epinephrine, while intracerebroventricular infusion of this substance had no effect on the incidence of epinephrine-induced arrhythmia. The selective antagonist of type I cannabinoid receptors SR141716A in a dose of 3 mg/kg and ganglion blocker hexamethonium in a dose of 10 mg/kg did not modify the antiarrhythmic effect of HU-210. This effect of HU-210 is probably related to activation of type II peripheral cannabinoid receptors.

PMID: 11182823 [PubMed - indexed for MEDLINE]

Source: Involvement of central and peripheral cannabinoid ... [Bull Exp Biol Med. 2000] - PubMed result
 
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