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How Concentrated Cannabis Oil Kills Cancer

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I'm asked this daily, so here goes:
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the "Sphingolipid Rheostat." If ceramide (a signaling metabolite of sphingosine-1- phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.

Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.

The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. the purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.

Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren't enough, ceramide disrupts the cellular lysosome, the cell's digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.

The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.

How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for it's matched exocannabinoid activator.

This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system andthe central nervous system (CNS). It is responsible for neuroprotection, and micro- manages the immune system. This is the primary control system that maintains homeostasis; our well being.

Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.

To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it's much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).

It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.

Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body's immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.

This post touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
 
Thanks Cajuncelt, where did you get this information, do you have a reference? Too bad our government chooses to keep antiquated laws on the books despite overwhelming evidence that cannabis may be one of the the most medicinal plants we have on earth. We should vote the bastards out of office until we find legislators that will put this medicine back in our hands once and for all. The majority of our doctors are dumfounded because the Federal law is so prohibitive oh well it is just a matter of time. On a side note most of the dispensaries here in Colorado are selling contaminated buds. There is widespread use of chemicals to control greenhouse problems so even though we have medical dispensary's most of them do not sell pharmaceutical grade medicine and it is extremely hard to find Rick Simpson Oil. Most of the oil sold is raw (cold processed with butane or CO2) and made for oil rigs. There are however, people on Craigslist selling RSO, so it is available at least for now. Colorado is trying to pass a law to limit home manufacture of concentrates due to the number of butane fires.
 
This is very encouraging though I am having a difficult time reading it. I have been advised to talk to Cajun Celtic for treating my wife. Is this you? I cannot message yet.
My wife has terminal cancer in her spleen, rectum, breast, etc. The spleen and rectum are the worst. She cannot be cured by chemo.
Please please give me all the information you can.
 
Dear GreenLiv,
I am very sorry to hear about your wife so I am replying to your post even though I am not cajuncelt. Even if your wife is not a is not a candidate for chemo she could try tacking oil to her gums. Here is the link on this forum: Cannabis Oil Dosing Tutorial - Tacking Method. This thread is lengthy but it is has (IMHO) the best advice for using cannabis oil to treat cancer. Basically there are 2 ways (other than smoking or vaping) to use cannabis oil which are tacking and consuming edibles. So far tacking is the best way we have to deliver enough THC directly to bloodstream and into the brain (because it passes the blood brain barrier) to be effective for cancer. Consuming edibles will control pain and inflammation but it will not deliver enough THC to the brain to treat serious forms of cancer.
Methodology is very important but finding quality oil of the right strain is critical. I live in the Denver area and could help if you need it.
 

KingstonRabbi

Well-Known Member
Great information from cajuncelt. At my last appointment with my oncologist I discussed the ATP issue. She admitted she knew nothing about MMJ or how it works. However, we discussed how ATP functions in cell energy. In conclusion she agreed that there is no way for cell to survive or develop resistance if THC does in fact block ATP production in cancer cells in vivo. She is still skeptical, but if my next scan (8 months post chemo) is clear she'll have to concede that cannabis does in fact treat cancer.:Namaste:
 
Cajon,

I have read your explanation here about 4 times and it has started to make sense to me. OK, I m a slow learner, so my wife says!

I posted a question in the cancer section about the long term effects of using RSO. I hope you can give me some insight.
 

SweetSue

Member of the Year: 2015 & 2016 - Member of the Month: Mar 2015, Sept 2016 - Nug of the Month: Oct 2017 - Creme de la Creme Photos: Dec 2016
This could stand to be made more readable. Whew! I can understand his resistance to try to explain that on a digital field.

Some vocabulary development might be the ticket to deeper understanding.

This is just cool to watch. :4: