SweetSue's Class Notes

[InTheShed]

 

[SweetSue]

My pleasure.

 

[SweetSue]

Random notes that I’ll add to later. I missed notes on the beginning where he talked about the biology of genetic modification.

5% of the brain has conscious intent

95% of the body is habitually programmed to the past

- the thought of intent can’t make it past the brain stem to the body with all this cluttering programming​

​

32:26 Change your emotions and you change your

• biology
• energetic state

^^^^Within you and all around you^^^^


What stands between me and the quantum field?

My expectation and the emotional response it creates. ​

34:10
98.5% of DNA is considered “junk DNA” because they can’t explain it.

It’s theorized we only use 1.5% of our DNA. From that:

• there 23, 688 genes expressed in the human body.
• there are 140,000 proteins expressed in the making of a typical human body.

Reason suggests that there should be a 1:1 ratio of gene to protein. Not so.

On one gene you can have thousands of expressions, depending on the signal.

• Joe hypothesizes that the ”junk DNA” is signaled by electromagnetism.
• Receptors are 100 times more responsive to electromagnetism (energy) than to chemistry.
  • Chemistry is a downward causation.

In an energized state the body creates new genes.​

- possibly ones that creates more significant and faster changes in the body​

​

It’s not matter that creates the field of infinite possibilities, it’s the field that creates matter. (Thoughts becoming....).

- Train yourself to live in that field and you shorten the gap between desire and change.​

Down-regulate genes for disease. Up-regulate genes for homeostasis.

The act of becoming is the act of overcoming.

We don’t see things as they are. We see things as we are.

Memory without the emotional charge is wisdom.

If you know that your thoughts create your reality and you know that means you have to accept the responsibility for your own life, but you can’t forgive yourself, you won’t want to play the game and evolve beyond the comfortable, miserable space you’re telling yourself can’t change.


Yeah...... not me Baby. Bubble of Joy.

 

[SweetSue]

Illustration by David S. Goodsell, The Scripps Research Institute (2011)

Mycoplasma mycoides
This illustration shows an entire mycoplasma cell.
© David S. Goodsell 2011.


View media item 1755118
View media item 1755119
Key
Protein synthesis (labels in black)
1. DNA
2. DNA polymerase
3. single-stranded-DNA binding protein (protects single-stranded portions during replication)
4. RNA polymerase
5. messenger RNA
6. ribosome
7. transfer RNA (in pink) and elongation factor Tu (in blue)
8. elongation factor Tu and Ts
9. elongation factor G
10. aminoacyl-tRNA synthetases
11. topoisomerases
12. Rec system for DNA repair: a) RecA, b) RecBC
13. chaperonin GroEL (helps folding of new proteins)
14. proteasome ClpA (destroys old proteins)
Enzymes for energy production (labels in red)
15. glycolytic enymes
16. pyruvate dehydrogenase complex
Membrane proteins (labels in blue)
17. ATP synthase
18. secretory proteins
19. sodium pump
20. zinc transporter
21. magnesium transporter
22. ABC transporter (different ABC transporters transport different types of molecules-ABC is short for "ATP-binding cassette")
23. magnesium transporter
24. lipoglycan (long carbohydrate chains connected to lipid in the membrane)



Mycoplasma mycoides is a bacterial species of the genus Mycoplasma in the class Mollicutes. This microorganism is a parasite that lives in ruminants. Mycoplasma mycoides comprises two subspecies, mycoides and capri, which infect cattle and small ruminants such as goats respectively.

 

[SweetSue]

Just reinforcing some facts.

At 11:17 of the Green Valley class on Cannabis and Cancer Myra mentions that their conventional treatment for cancer is 3:1 THC:CBD.

• If things don’t go right and you suspect it’s may be a complication of the ID-1 gene flip that ratio and see how it goes.

The ID-1 gene is proliferative. CBD shuts down that expression so the cancer cell with this gene can’t grow and spread.

 

[SweetSue]

Notes from Michael BaCoke’s’ “Cannabis Pharmacy” on cannabis and pain m

Effectiveness of cannabis therapeutics

Different types of pain:

• neuropathic (originating in nerves)
  • diabetic neuropathy
  • sciatica
• visceral (originating in an organ)
  • menstrual cramps
• somatic (in musculoskeletal tissue or the skin underlying soft tissues)
  • arthritis
  • post-surgical pain
• psychogenetic
  • panic attack
  • tension headache

Cannabis is proven effective against all types of pain

• more effective for chronic pain
• seem to be less effective for acute pain under current protocols

UC San Diego study on Sativex cannabinoid spray showed cannabis most effective for pain at low to moderate doses

• higher doses don’t necessarily provide more relief
• higher doses may, in fact, make things hurt more

Pain-relieving effects of cannabis are statistically significant.

May be effective for pain-related syndromes that don’t respond well to traditional analgesics

• Complex regional pain
• reflex sympathetic dystrophy
• neuropathies
• intractable cancer pain

Many studies found that higher dose inhaled cannabis offered no more pain relief than low-dose, but got people higher than they were comfortable with (which is what they really mean when they say “more negative cognitive side effects)

I always find myself wondering who exactly decided that the high was a negative side effect. If it was the participants, that’s one thing. If the intent of the study was to consider getting high as a negative effect then it’s not so cool, is it?

No studies have shown effectiveness against trigeminal neuralgia, numerous anecdotal accounts suggest patients are finding relief.

Case reports show cancer patients feel less anxious, a tremendous benefit since anxiety heightens pain perception.

• A typical dose of 10 mg THC is as effective as 60 mg of coding, but without the opioid side-effects.
• Cancer patients report relief from
  • neuropathic pain
  • visceral (organ) pain

Clinical data indicates cannabis medicines may reduce opioid doses required for severe pain.

• can decrease dose
• may restore a healthier response of opioid system that was previously lost from using opioids, making opioids more effective
• cannabinoids can provide adjunct therapies to opioids
• may also reduce tolerance buildup to opioids
• CBD reduces severity of withdrawal
• THC reduces gastrointestinal bleeding and hemorrhages caused by nonsteroidal ant—inflammatories

Cannabinoids, particularly the combo of THC and CBD appear particularly effective for intractable pain conditions, incl

• multiple sclerosis
• cancer

CGB is a stronger analgesic than THC

THCV (not as psychoactive as THC) has also been shown to reduce severe pain

Mechanisms of Action

The ECS modulates Pain through the nervous system

Cannabinoids

• produce analgesic effects
• produce anti-inflammatory relief

They do so

• by modulating neurotransmitter release
• by stimulating release of the body’s own endogenous opioids

THC shows great potential for treatment of opioid addiction and to reduce OD deaths by

• displacing opioid molecule at their own opioid receptors
• allowing for reduction of opioid medicines to control pain

eCBs also reduce

• wind-up phenomena (when pain seems to increase in intensity as pain stimulus is repeated)
• allodynia (Pain from stimulus not normally considered painful)

Cannabinoids

• quell ascending transmissions of pain (traveling toward spine and brain)
• modulate descending pain signaling (away from brain/spine to affected area)

The ECS (an possibly a deficiency thereof) contribute to painful syndromes like

• fibromyalgia
• migraines

These conditions may be treatable with low-dose cannabis medicines

Dosages

Start low. Go slow. Stay low
​

Methods of Ingestion

patients report oral cannabis works for chronic pain

- it takes patience and thoughtfulness to find proper dose​

​

Cannabis is excellent for restorative sleep and reducing pain perception at night

Including THC in the oral dose

• increases therapeutic window for pain relief while you sleep​
• increases the time you sleep​
• increases the perceived potency of the formulation​

Some patients achieve pain relief during the day with smaller doses of edibles in morning and afternoon

- approx. 1/4 the bedtime dose​

Patients report that cannabis medicines inhaled, as sublingual tincture, or oral spray

• removes anticipatory bad pain memories (just as it does for PTSD)
• Decreases intensity of pain experience
• calms the patient
• lessens secondary adrenaline response to pain

Cannabis provides a calming euphoric experience to offset the dysphoric effects of pain and helps patient let the pain memory go

• gives patients a sense of control over their pain

Any reductions in opioid doses should be undertaken under the watchful eye of the prescribing physician.

Oral dosing

• doses can take 45 minutes to an hour or longer to take effect
• better for chronic pain
  • inhaling causes rapid spike in blood serum cannabinoids that doesn’t benefit chronic pain

Use THC and CBD together

• CBD extends the therapeutic window and effectiveness of THC
• CBD reduces rapid heart rate and anxiety sometimes caused by THC

Controlling pain with oral doses

• 2.5 - 7.5 mg THC every 3-4 hours for moderate pain
• add 2.5 - 10 mg CBD to temper euphoria and potentiate THC
  • will also provide a measure of neuroprotection

Remember cannabis has an individual sweet spot for each patient for pain relief

• Be careful not to overshoot the MED, because it may mean increased pain

Controlling pain with vaporization or smoking

• 2.5 - 7.5 mg THC
• novice patients start with no more than 2.5 mg
  • about the size of a matchstick-head-sized piece of flower bud
  • wait ~ 40 minutes before taking any more
• much faster onset than oral
• good for breakthrough pain and spasms

Topical Treatments

• Pain must be localized
  • usually to joint or peripheral nerve
• preparation should be high THC and possibly some CBD
  • We now know that THCa is also a good addition to topicals.

How cannabis topicals work

• we believe they stimulate CB2 receptors in sensory nerve endings in the skin

typically two hour’s relief, sometimes longer

Useful to treat

• itching
• skin irritations
• dermatitis
• CBD-rich effective for skin inflammation

***May also be synergistic with capsaicin-based ointments used for muscle pain***

Topical preparations containing THC (hydrophilic) have little or no absorption through the skin

• no psychoactivity
• little, if any anti-inflammatory effect

Many patients find the lack of euphoria with topicals an asset as they have social obligations or little desire to get high

- can treat joint or neuropathy pain during the day without any fear of a buzz​

​

I’ve begun wondering lately with all the current hoopla about euphoria and topicals if there’s been any cases of this actually occurring? ​

If anyone reading this hears of one I’d appreciate a ”heads up!”
​

Topical CBD has some absorption

• some patients claim relief
• no studies back up these claims

Placebo? Possibly added terpenes? I’ve been wondering about this myself, because I know athletes who’ve used CBD creams and had great relief, but none of them could produce a jar with any useful information on it, so it remains a mystery.

Indicated chemotypes

Most will be effective on pain, at some level (most have myrcene)

THC is the most important cannabinoid currently available for pain relief.

• CBD and terpenes contribute significantly to
  • pain relief
  • anxiety relief
  • restorative rest

The choice of cultivar depends on whether

• patient needs more stimulation for daytime
• more sedation to assist with
  • recovery
  • sleep

High-CBD work well for neuropathic pain

High-THC better for

• distraction
• sleep support

Chemovars with small amounts of CBG will likely increase pain-relieving effect (i.e. Skunk varieties)

Myrcene is known for analgesia and sedation

Cannabis with purple flowers are usually

• high in myrcene
• high in THC
• occassionally expressing considerable linalool

all of the above list are known analgesics

Beta-caryophyllene (i.e. Cookies varieties, Kryptonite)

• powerful anti-inflammatory
• synergystic with THC in protecting gut from effects of non-steroidal, anti-inflammatory pain meds
• confirmed in rodent models to lessen pain and the perception of it (nociception)
• shown to be equal to or more effective than CBD for anti-inflammatory effects
• when used alone
  • reduced drug administration (dose volumes?)
  • improved scores of depression (rodents)
  • reduced scores of anxiety (rodents)

For intractable pain or chronic pain syndromes

• CBD/THC varieties are effective
• significant amounts of CBD and THC (i.e. Harlequin, Rainbow Gumeez) may reduce psychoactivity
  • may not be optimal for for some types of pain, where euphoria can distract from the pain
  • may provide anti-inflammatory properties

If psychoactivity is inappropriate extremely low-THC/high-CBD varieties (i.e. ACDC) can be effective for

• inflammatory pain
• neuropathic pain

 

[SweetSue]

Notes from Michael Backes’’ “Cannabis Pharmacy” on cannabis and pain

Effectiveness of cannabis therapeutics

Different types of pain:

• neuropathic (originating in nerves)
  • diabetic neuropathy
  • sciatica
• visceral (originating in an organ)
  • menstrual cramps
• somatic (in musculoskeletal tissue or the skin underlying soft tissues)
  • arthritis
  • post-surgical pain
• psychogenetic
  • panic attack
  • tension headache

Cannabis is proven effective against all types of pain

• more effective for chronic pain
• seem to be less effective for acute pain under current protocols

UC San Diego study on Sativex cannabinoid spray showed cannabis most effective for pain at low to moderate doses

• higher doses don’t necessarily provide more relief
• higher doses may, in fact, make things hurt more

Pain-relieving effects of cannabis are statistically significant.

May be effective for pain-related syndromes that don’t respond well to traditional analgesics

• Complex regional pain
• reflex sympathetic dystrophy
• neuropathies
• intractable cancer pain

Many studies found that higher dose inhaled cannabis offered no more pain relief than low-dose, but got people higher than they were comfortable with (which is what they really mean when they say “more negative cognitive side effects)

I always find myself wondering who exactly decided that the high was a negative side effect. If it was the participants, that’s one thing. If the intent of the study was to consider getting high as a negative effect then it’s not so cool, is it?

No studies have shown effectiveness against trigeminal neuralgia, numerous anecdotal accounts suggest patients are finding relief.

Case reports show cancer patients feel less anxious, a tremendous benefit since anxiety heightens pain perception.

• A typical dose of 10 mg THC is as effective as 60 mg of coding, but without the opioid side-effects.
• Cancer patients report relief from
  • neuropathic pain
  • visceral (organ) pain

Clinical data indicates cannabis medicines may reduce opioid doses required for severe pain.

• can decrease dose
• may restore a healthier response of opioid system that was previously lost from using opioids, making opioids more effective
• cannabinoids can provide adjunct therapies to opioids
• may also reduce tolerance buildup to opioids
• CBD reduces severity of withdrawal
• THC reduces gastrointestinal bleeding and hemorrhages caused by nonsteroidal ant—inflammatories

Cannabinoids, particularly the combo of THC and CBD appear particularly effective for intractable pain conditions, incl

• multiple sclerosis
• cancer

CGB is a stronger analgesic than THC

THCV (not as psychoactive as THC) has also been shown to reduce severe pain

Mechanisms of Action

The ECS modulates Pain through the nervous system

Cannabinoids

• produce analgesic effects
• produce anti-inflammatory relief

They do so

• by modulating neurotransmitter release
• by stimulating release of the body’s own endogenous opioids

THC shows great potential for treatment of opioid addiction and to reduce OD deaths by

• displacing opioid molecule at their own opioid receptors
• allowing for reduction of opioid medicines to control pain

eCBs also reduce

• wind-up phenomena (when pain seems to increase in intensity as pain stimulus is repeated)
• allodynia (Pain from stimulus not normally considered painful)

Cannabinoids

• quell ascending transmissions of pain (traveling toward spine and brain)
• modulate descending pain signaling (away from brain/spine to affected area)

The ECS (an possibly a deficiency thereof) contribute to painful syndromes like

• fibromyalgia
• migraines

These conditions may be treatable with low-dose cannabis medicines

Dosages

Start low. Go slow. Stay low
​

Methods of Ingestion

patients report oral cannabis works for chronic pain

- it takes patience and thoughtfulness to find proper dose​

​

Cannabis is excellent for restorative sleep and reducing pain perception at night

Including THC in the oral dose

• increases therapeutic window for pain relief while you sleep​
• increases the time you sleep​
• increases the perceived potency of the formulation​

Some patients achieve pain relief during the day with smaller doses of edibles in morning and afternoon

- approx. 1/4 the bedtime dose​

Patients report that cannabis medicines inhaled, as sublingual tincture, or oral spray

• removes anticipatory bad pain memories (just as it does for PTSD)
• Decreases intensity of pain experience
• calms the patient
• lessens secondary adrenaline response to pain

Cannabis provides a calming euphoric experience to offset the dysphoric effects of pain and helps patient let the pain memory go

• gives patients a sense of control over their pain

Any reductions in opioid doses should be undertaken under the watchful eye of the prescribing physician.

Oral dosing

• doses can take 45 minutes to an hour or longer to take effect
• better for chronic pain
  • inhaling causes rapid spike in blood serum cannabinoids that doesn’t benefit chronic pain

Use THC and CBD together

• CBD extends the therapeutic window and effectiveness of THC
• CBD reduces rapid heart rate and anxiety sometimes caused by THC

Controlling pain with oral doses

• 2.5 - 7.5 mg THC every 3-4 hours for moderate pain
• add 2.5 - 10 mg CBD to temper euphoria and potentiate THC
  • will also provide a measure of neuroprotection

Remember cannabis has an individual sweet spot for each patient for pain relief

• Be careful not to overshoot the MED, because it may mean increased pain

Controlling pain with vaporization or smoking

• 2.5 - 7.5 mg THC
• novice patients start with no more than 2.5 mg
  • about the size of a matchstick-head-sized piece of flower bud
  • wait ~ 40 minutes before taking any more
• much faster onset than oral
• good for breakthrough pain and spasms

Topical Treatments

• Pain must be localized
  • usually to joint or peripheral nerve
• preparation should be high THC and possibly some CBD
  • We now know that THCa is also a good addition to topicals.

How cannabis topicals work

• we believe they stimulate CB2 receptors in sensory nerve endings in the skin

typically two hour’s relief, sometimes longer

Useful to treat

• itching
• skin irritations
• dermatitis
• CBD-rich effective for skin inflammation

***May also be synergistic with capsaicin-based ointments used for muscle pain***

Topical preparations containing THC (hydrophilic) have little or no absorption through the skin

• no psychoactivity
• little, if any anti-inflammatory effect

Many patients find the lack of euphoria with topicals an asset as they have social obligations or little desire to get high

- can treat joint or neuropathy pain during the day without any fear of a buzz​

​

I’ve begun wondering lately with all the current hoopla about euphoria and topicals if there’s been any cases of this actually occurring? ​

​

If anyone reading this hears of one I’d appreciate a ”heads up!” ​

​

Topical CBD has some absorption

• some patients claim relief
• no studies back up these claims

Placebo? Possibly added terpenes? I’ve been wondering about this myself, because I know athletes who’ve used CBD creams and had great relief, but none of them could produce a jar with any useful information on it, so it remains a mystery.

Indicated chemotypes

Most will be effective on pain, at some level (most have myrcene)

THC is the most important cannabinoid currently available for pain relief.

• CBD and terpenes contribute significantly to
  • pain relief
  • anxiety relief
  • restorative rest

The choice of cultivar depends on whether

• patient needs more stimulation for daytime
• more sedation to assist with
  • recovery
  • sleep

High-CBD work well for neuropathic pain

High-THC better for

• distraction
• sleep support

Chemovars with small amounts of CBG will likely increase pain-relieving effect (i.e. Skunk varieties)

Myrcene is known for analgesia and sedation

Cannabis with purple flowers are usually

• high in myrcene
• high in THC
• occassionally expressing considerable linalool

all of the above list are known analgesics

Beta-caryophyllene (i.e. Cookies varieties, Kryptonite)

• powerful anti-inflammatory
• synergystic with THC in protecting gut from effects of non-steroidal, anti-inflammatory pain meds
• confirmed in rodent models to lessen pain and the perception of it (nociception)
• shown to be equal to or more effective than CBD for anti-inflammatory effects
• when used alone
  • reduced drug administration (dose volumes?)
  • improved scores of depression (rodents)
  • reduced scores of anxiety (rodents)

For intractable pain or chronic pain syndromes

• CBD/THC varieties are effective
• significant amounts of CBD and THC (i.e. Harlequin, Rainbow Gumeez) may reduce psychoactivity
  • may not be optimal for for some types of pain, where euphoria can distract from the pain
  • may provide anti-inflammatory properties

If psychoactivity is inappropriate extremely low-THC/high-CBD varieties (i.e. ACDC) can be effective for

• inflammatory pain
• neuropathic pain

I’m learning to laugh at my inability to edit a lengthy post. I just reprint with edits.

 

[SweetSue]

Notes from Michael BaCoke’s’ “Cannabis Pharmacy” on cannabis and pain m

Effectiveness of cannabis therapeutics

Different types of pain:

• neuropathic (originating in nerves)
  • diabetic neuropathy
  • sciatica
• visceral (originating in an organ)
  • menstrual cramps
• somatic (in musculoskeletal tissue or the skin underlying soft tissues)
  • arthritis
  • post-surgical pain
• psychogenetic
  • panic attack
  • tension headache

Cannabis is proven effective against all types of pain

• more effective for chronic pain
• seem to be less effective for acute pain under current protocols

UC San Diego study on Sativex cannabinoid spray showed cannabis most effective for pain at low to moderate doses

• higher doses don’t necessarily provide more relief
• higher doses may, in fact, make things hurt more

Pain-relieving effects of cannabis are statistically significant.

May be effective for pain-related syndromes that don’t respond well to traditional analgesics

• Complex regional pain
• reflex sympathetic dystrophy
• neuropathies
• intractable cancer pain

Many studies found that higher dose inhaled cannabis offered no more pain relief than low-dose, but got people higher than they were comfortable with (which is what they really mean when they say “more negative cognitive side effects)

I always find myself wondering who exactly decided that the high was a negative side effect. If it was the participants, that’s one thing. If the intent of the study was to consider getting high as a negative effect then it’s not so cool, is it?

No studies have shown effectiveness against trigeminal neuralgia, numerous anecdotal accounts suggest patients are finding relief.

Case reports show cancer patients feel less anxious, a tremendous benefit since anxiety heightens pain perception.

• A typical dose of 10 mg THC is as effective as 60 mg of codine, but without the opioid side-effects.
• Cancer patients report relief from
  • neuropathic pain
  • visceral (organ) pain

Clinical data indicates cannabis medicines may reduce opioid doses required for severe pain.

• can decrease dose
• may restore a healthier response of opioid system that was previously lost from using opioids, making opioids more effective
• cannabinoids can provide adjunct therapies to opioids
• may also reduce tolerance buildup to opioids
• CBD reduces severity of withdrawal
• THC reduces gastrointestinal bleeding and hemorrhages caused by nonsteroidal ant—inflammatories

Cannabinoids, particularly the combo of THC and CBD appear particularly effective for intractable pain conditions, incl.

• multiple sclerosis
• cancer

CGB is a stronger analgesic than THC

THCV (not as psychoactive as THC) has also been shown to reduce severe pain

Mechanisms of Action

The ECS modulates pain through the nervous system

Cannabinoids

• produce analgesic effects
• produce anti-inflammatory relief

They do so

• by modulating neurotransmitter release
• by stimulating release of the body’s own endogenous opioids

THC shows great potential for treatment of opioid addiction and to reduce opioid OD deaths by

• displacing opioid molecule at their own opioid receptors
• allowing for reduction of opioid medicines to control pain

eCBs also reduce

• wind-up phenomena (when pain seems to increase in intensity as pain stimulus is repeated)
• allodynia (pain from stimulus not normally considered painful)

Cannabinoids

• quell ascending transmissions of pain (traveling toward spine and brain)
• modulate descending pain signaling (away from brain/spine to affected area)

The ECS (an possibly a deficiency thereof) contribute to painful syndromes like

• fibromyalgia
• migraines

These conditions may be treatable with low-dose cannabis medicines

Dosages

Start low. Go slow. Stay low
​

Methods of Ingestion

patients report oral cannabis works for chronic pain

- it takes patience and thoughtfulness to find proper dose​

​

Cannabis is excellent for restorative sleep and reducing pain perception at night

Including THC in the oral dose

• increases therapeutic window for pain relief while you sleep​
• increases the time you sleep​
• increases the perceived potency of the formulation​

Some patients achieve pain relief during the day with smaller doses of edibles in morning and afternoon

- approx. 1/4 the bedtime dose​

Patients report that cannabis medicines inhaled, as sublingual tincture, or oral spray

• removes anticipatory bad pain memories (just as it does for PTSD)
• Decreases intensity of pain experience
• calms the patient
• lessens secondary adrenaline response to pain

Cannabis provides a calming euphoric experience to offset the dysphoric effects of pain and helps patient let the pain memory go

• gives patients a sense of control over their pain

Any reductions in opioid doses should be undertaken under the watchful eye of the prescribing physician.

Oral dosing

• doses can take 45 minutes to an hour or longer to take effect
• better for chronic pain
  • inhaling causes rapid spike in blood serum cannabinoids that doesn’t benefit chronic pain

Use THC and CBD together

• CBD extends the therapeutic window and effectiveness of THC
• CBD reduces rapid heart rate and anxiety sometimes caused by THC

Controlling pain with oral doses

• 2.5 - 7.5 mg THC every 3-4 hours for moderate pain
• add 2.5 - 10 mg CBD to temper euphoria and potentiate THC
  • will also provide a measure of neuroprotection

Remember cannabis has an individual sweet spot for each patient for pain relief

• Be careful not to overshoot the MED, because it may mean increased pain

Controlling pain with vaporization or smoking

• 2.5 - 7.5 mg THC
• novice patients start with no more than 2.5 mg
  • about the size of a matchstick-head-sized piece of flower bud
  • wait ~ 40 minutes before taking any more
• much faster onset than oral
• good for breakthrough pain and spasms

Topical Treatments

• Pain must be localized
  • usually to joint or peripheral nerve
• preparation should be high THC and possibly some CBD
  • We now know that THCa is also a good addition to topicals.

How cannabis topicals work

• we believe they stimulate CB2 receptors in sensory nerve endings in the skin

typically two hour’s relief, sometimes longer

Useful to treat

• itching
• skin irritations
• dermatitis
• CBD-rich effective for skin inflammation

***May also be synergistic with capsaicin-based ointments used for muscle pain***

Topical preparations containing THC (hydrophilic) have little or no absorption through the skin

• no psychoactivity
• little, if any anti-inflammatory effect

Many patients find the lack of euphoria with topicals an asset as they have social obligations or little desire to get high

- can treat joint or neuropathy pain during the day without any fear of a buzz​

​

I’ve begun wondering lately with all the current hoopla about euphoria and topicals if there’s been any cases of this actually occurring? ​

​

If anyone reading this hears of one I’d appreciate a ”heads up!” ​

​

Topical CBD has some absorption

• some patients claim relief
• no studies back up these claims

Placebo? Possibly added terpenes? I’ve been wondering about this myself, because I know athletes who’ve used CBD creams and had great relief, but none of them could produce a jar with any useful information on it, so it remains a mystery.

Indicated chemotypes

Most will be effective on pain, at some level (most have myrcene)

THC is the most important cannabinoid currently available for pain relief.

• CBD and terpenes contribute significantly to
  • pain relief
  • anxiety relief
  • restorative rest

The choice of cultivar depends on whether

• patient needs more stimulation for daytime
• more sedation to assist with
  • recovery
  • sleep

High-CBD work well for neuropathic pain

High-THC better for

• distraction
• sleep support

Chemovars with small amounts of CBG will likely increase pain-relieving effect (i.e. Skunk varieties)

Myrcene is known for analgesia and sedation

Cannabis with purple flowers are usually

• high in myrcene
• high in THC
• occassionally expressing considerable linalool

all of the above list are known analgesics

Beta-caryophyllene (i.e. Cookies varieties, Kryptonite)

• powerful anti-inflammatory
• synergystic with THC in protecting gut from effects of non-steroidal, anti-inflammatory pain meds
• confirmed in rodent models to lessen pain and the perception of it (nociception)
• shown to be equal to or more effective than CBD for anti-inflammatory effects
• when used alone
  • reduced drug administration (dose volumes?)
  • improved scores of depression (rodents)
  • reduced scores of anxiety (rodents)

For intractable pain or chronic pain syndromes

• CBD/THC varieties are effective
• significant amounts of CBD and THC (i.e. Harlequin, Rainbow Gumeez) may reduce psychoactivity
  • may not be optimal for for some types of pain, where euphoria can distract from the pain
  • may provide anti-inflammatory properties

If psychoactivity is inappropriate extremely low-THC/high-CBD varieties (i.e. ACDC) can be effective for

• inflammatory pain
• neuropathic pain

 

[SweetSue]

There, I think I got it right that time.

 

[SweetSue]

I do believe I’ll take the rest of the day and just chill.

Yeah...... like we believe that’ll happen. I find I have a challenge slowing down when it’s so much fun. Too much can lead to burn out. I’ve watched it happen to others over and over, and I have no desire to fall into that trap.

This is still the best retirement plan I’ve yet encountered for someone with my energetic and curious mind. I love picking this stuff apart. It struck me as funny that we as writers go through a lot of work getting our words to entice and teach, and I’ve discovered that there are significant numbers of people who want to learn it, but can’t fight their way through the words.

So I break it all down back into the notes he probably used to construct his beautifully-written book.

Worth remembering when I write my own.

 

[SweetSue]

The Cannabis Health Index - Uwe Blesching, PhD

Pain (in general)

Pain is a warning system meant to get our attention so we can do something effective to stop the pain.

• it’s a feedback and protective device
• it can motivate new choices
• it can inspire you to avoid choices that lead to pain
• pain calls immediate attention to the affected area
• worse pain = more acute demand for attention
  • true for both acute or sudden pain as well as chronic pain
• Pain demands change

Pain can be a terribly destructive emotion

• producing isolation and exhaustion
• people numb themselves from the effects of pain
  • ignore it
  • deny it
  • mask it

These responses ensure the continuation of the pain cycle

• eventually it’ll re-emerge and amplify

Pain begins as an emotional reality; deal with it or pay the eventual price

• avoided pain from perceived betrayal and humiliation can create autoimmune disorders
• aggravating factors include
  • guilt
  • belief in punishment
• consider emotional plane work on releasing
  • guilt
  • grief
  • pain
  • hurt

Forgiveness and self love go a long way to augmenting internal healing atmospheres

Affects

• body
• mind
• quality of life
• overall well-being

Highly subjective experience

• people have significantly different thresholds
• cultural factors influence experience

Creates unpleasant sensory and emotional experiences due to

• injury
• threat of injury

Nociceptors are present throughout the body

• Skin
• blood vessels
• muscle tissue
• organs
• other strategic parts of the body

Nociceptors are stimulated by the threat or presence of pain from

• heat
• pressure
• chemicals

Upon stimulation, rapid signals produce complex changes to

• affected tissue
• CNS

These changes increase

• respiration
• heart beat
• blood pressure

Body and mind quickly respond to

• stop or minimize pain
• ensure survival

Pain is the main reason for seeking medical attention

Pain specialists separate pain into

• neuropathic pain (usually chronic)
• nociceptive pains (usually time-limited)

Further differentiation:

• referred pain: present at a distance from the point of origin (i.e. radiating heart attack pains)
• visceral pain: associated with associated organ, but not necessarily localized (i.e. liver or bowels)
• parietal pains:
  • normally presents at precise location
  • claim association with inflammation at lining of organs

eCB1Rs

eCB1Rs are primarily found in the CNS, which

• controls sensory information
• enables response reactions and behavior

eCB1Rs are located in parts of the brain that regulate

• motor control
• attention
• emotion
• thinking (cerebellum)
• habits (basal ganglia and limbic system)
• memory functions (hippocampus)

eCB1Rs also found in male and female reproductive systems

eCB1Rs are absent in the medulla oblongata, the part of the brain that regulates

• respiration function
• heart function

Cannabinoids are safer than opioids, because suppression of these areas is what often kills or damages opioid ODs.

Cannabinoids can’t replace opioids for new trauma or injury

• can work in synergy with reduced opioid dose to affect pain control
• reduced risk of adverse effects and addiction that often accompanies opiates
• a reduced dose of both is more effective than a high dose of either alon

eCB2Rs

Cluster primarily in periphery, esp. in tissue of immune system

• spleen houses high concentrations of eCB2Rs

eCB2R engagement important for treatment of chronic pain of autoimmune diseases

An overview of existing studies between 2004-2009 determined cannabinoids effective for relief of inflammatory pain associated with

• post-surgery
• rheumatism
• rheumatoid arthritis
• chronic neuropathic pain
• fibromyalgia

Cannabis has potential to assist healing by

• decreasing inflammatory pain
• decreasing inflammation
• sparing opioid doses
• reducing painful muscle spasm
• diminishing anxiety of anticipated pain
• inducing rest and sleep
• gently elevating the mood

In a 2009 study at UC San Diego they demonstrated the importance of dose to therapeutic effectiveness

• 15 healthy volunteers received injections of capsaicin in opposite forearms
• injections spaced at 5 and 45 minute intervals after smoking cannabis
• three different concentrations
  • 2%, 4%, 8% THC by weight
• measured
  • pain levels
  • pain thresholds
• 5 min after cannabis exposure = no relief at any dose
• 45 min after exposure
  • significant decrease in capsaicin-induced pain with the medium dose
  • significant increase in capsaicin-induced pain the high dose

With chronic pain in particular, the minimum therapeutic dose is worth paying attention to.



It’s worth remembering that the high dose was a mere 8mg of THC. In all likelihood, with a 1:1 ratio and some valuable terpenes you can manage pain quite effectively with doses below 10mg of THC.



Powerful Questions I love the way Uwe takes it to another healing level.



What is my pain keeping me from doing?

How do I feel about it?

What am I separated from and what am I longing for?

Is this pain pointing to some unfinished loss or grief?

Am I masking pain with punishing guilt?

Am I avoiding pain with numbing judgements and prejudices?

Am I denying pain by numbing it with self-pity?

Am I constantly avoiding pain with numbing medications?

Am I avoiding pain with imprisoning depression?

Am I running from pain by becoming addicted or obsessed?

Am I avoiding pain by focusing on blame and betrayal?



Tomorrow I’ll get into his coverage of particular pain cycles.

 

[SweetSue]

An excellent resource for many things. This page alone was deliciously interactive.

Source: Pain Principles: UTHealth

Chapter 6: Pain Principles

Nachum Dafny, Ph.D., Department of Neurobiology and Anatomy, McGovern Medical School

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6.4 Pain Fibers

The cell bodies of the primary afferent pain neurons from the body, face, and head are located in the dorsal root ganglia (DRG) and in the trigeminal ganglia respectively. Some of these cell bodies give rise to myelinated axons (A delta fibers), and others give rise to unmyelinated axons (C fibers). The free nerve endings arise from both A delta fibers and the unmyelinated C fibers, which are scattered together (Figure 6.9).

A delta fibers (group III fibers) are 2-5 mm in diameter, myelinated, have a fast conduction velocity (5-40 meters/sec), and carry information mainly from the nociceptive-mechanical or mechanothermal-specific nociceptors. Their receptive fields are small. Therefore, they provide precise localization of pain.

C fibers (group IV fibers) are 0.4-1.2 mm in diameter, unmyelinated, have a slow conduction velocity (0.5-2.0 meters/sec), and are activated by a variety of high-intensity mechanical, chemical and thermal stimulation and carry information from polymodal nociceptors. C-fibers comprise about 70% of all the fibers carrying noxious input. Two classes of C-fibers have been identified. The receptive field of these neurons is large and, therefore, less precise for pain localization.

Upon entering the spinal cord, the pain fibers bifurcate and ascend and descend to several segments, forming part of the tract of Lissauer before synapsing on neurons on Rexed layers I to II. In general, nociceptors responding to noxious stimuli transmit the information to the CNS via A delta fibers, which make synaptic connections to neurons in Rexed layer I (nucleus posterior marginalis). The nociceptors responding to chemical or thermal stimuli (i.e., the polymodal nociceptors) carry their activity mainly by C unmyelinated fibers. One class of C fibers terminates in Rexed layer I, and the second class terminates in Rexed layer II (substantia gelatinosa). These fibers release substance P, glutamate, aspartate calcitonin gene related peptide (CGRP), vasoactive intestinal polypeptide (VIP), and nitric oxide.

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6.5 Double Pain Sensations

Two sequential pain sensations in short time intervals is the result of sudden painful stimulation. The first one is immediately after the damage. It is followed several seconds later with additional pain sensation. These two separate sensations are several seconds apart because a fast transmitting information sensation is carried via A delta fibers and is followed several seconds later with slow transmitting pain information carried via C fibers. This phenomenon is known as “double pain sensation” (Figure 6.9).

Two experimental procedures were used to verify which information is carried by which fibers.

1. Externally applied pressure, such as compression of the skin above a nerve, first blocks the myelinated A delta fibers, while C fibers continue to conduct action potentials and allow the slow conducting pain to be carried.
2. A low dose of local anesthesia applied to peripheral nerves blocks theunmyelinated C fibers before the myelinated A delta fibers. Under this condition, the slow conducting pain information is blocked, and only the fast conducting pain information by A delta fibers is carried to the CNS. This experiment provides additional evidence that two different types of nerve fibers carry noxious information.

6.6 Nociceptive Neurons in the Spinal Cord (Nocineurons)

The synaptic terminals of the axons of the dorsal root ganglion, which carry noxious information arriving to Rexed layers I and II (Figure 6.10), release neurochemical agents such as substance P (SP), glutamate, aspartate, vasoactive intestinal peptide (VIP), cholecystokinin (CCK), somatostatin, calcitonin gene-related peptide (CGRP), galanin, and other agents. These agents activate the nocineurons. It was shown that when SP and CGRP are applied locally within the spinal cord dorsal horn, glutamate is released. The release of glutamate excites the nocineurons. Furthermore, SP receptors (neurokinin receptors) and NMDA receptors (glutamate) interact which result that the NMDA receptors will become more sensitive to glutamate, which results in central sensitization. The functions of these peptides are largely unknown but they presumably mediate slow, modulatory synaptic actions in the dorsal horn neurons. The neuropeptides are always co-localized with other "classical" neurotransmitters.

There are four general types of nocineurons in the spinal cord (Figure 6.10):

1. High threshold mechanoreceptor neurons or nociceptive specific neurons. These neurons are excited only by noxious cutaneous and/or visceral stimuli. The nociceptive afferent fibers release glutamate and different neuropeptides to activate the dorsal horn neurons.
2. Chemical nociceptor neurons are excited by chemical or thermal noxious stimulus in the skin or in visceral organs.
3. Thermal nociceptor neurons are excited by chemical or thermal noxious stimulus in the skin or in visceral organs.
4. Polymodal-nociceptive neurons or multi, or wide dynamic range nociceptive neurons. These neurons are excited by both noxious and non-noxious cutaneous and/or visceral stimuli (polymodal nociceptive neurons). These neurons are activated by a variety of noxious stimuli (mechanical, thermal, chemical, etc.) and respond incrementally to increasing intensity of the stimuli.

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Rexed lamina I contains a higher proportion of nociceptive specific neurons, whereas Rexed lamina II contains predominantly multi-receptive wide dynamic range neurons. The nociceptive-specific neurons alert the subject when a stimulus is noxious, and the multi-receptive neurons provide the subject with information about the parameters of the noxious stimulus. In general, C fibers release neuropeptides such as substance P whereas the A delta fibers release glutamate.

[...]
6.7 Classification of Pain

Pain has been classified into three major types:

1. Pricking pain. Pain caused by a needle, pin prick, skin cut, etc. - elicits a sharp, pricking quality, stinging pain sensation carried fast by the A delta fibers. The pain is precisely localized and of short duration. Pricking pain is also called fast pain, first pain or sensory pain. Pricking pain is present in all individuals and is a useful and necessary component of our sensory repertoire. Without this type of protective pain sensation, everyday life would be difficult. Pricking pain arises mainly from the skin, and carried mainly by A delta fibers which permits discrimination (i.e., permits the subject to localize the pain)
2. Burning pain or soreness pain. Pain caused by inflammation, burned skin, etc., is carried by the C fibers (slowly conducted pain nerve fibers). This type of pain is a more diffuse, slower to onset, and longer in duration. It is an annoying pain and intolerable pain, which is not distinctly localized. Like pricking pain, burning pain arises mainly from the skin. It is carried by the paleospinothalamic tract. (The old primitive transmission system for diffuse pain which does not permit exact localization.)
3. Aching pain is a sore pain. This pain arises mainly from the viscera and somatic deep structures. Aching pain is not distinctly localized and is an annoying and intolerable pain. Aching pain is carried by the C fibers from the deep structures to the spinal cord.

 

[SweetSue]

Source

Original Paper Published: 19 January 2019

A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects


Nadia Solowij, Samantha Broyd, Rodney Croft

European Archives of Psychiatry and Clinical Neuroscience, volume 269, pages 17- 35(2019)

Abstract

Access to cannabis and cannabinoid products is increasing worldwide for recreational and medicinal use. Two primary compounds within cannabis plant matter, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are both psychoactive, but only THC is considered intoxicating. There is significant interest in potential therapeutic properties of these cannabinoids and of CBD in particular.
Some research has suggested that CBD may ameliorate adverse effects of THC, but this may be dose dependent as other evidence suggests possible potentiating effects of THC by low doses of CBD. We conducted a randomised placebo controlled trial to examine the acute effects of these compounds alone and in combination when administered by vaporisation to frequent and infrequent cannabis users. Participants (n = 36; 31 male) completed 5 drug conditions spaced one week apart, with the following planned contrasts: placebo vs CBD alone (400 mg); THC alone (8 mg) vs THC combined with low (4 mg) or high (400 mg) doses of CBD. Objective (blind observer ratings) and subjective (self-rated) measures of intoxication were the primary outcomes, with additional indices of intoxication examined. CBD showed some intoxicating properties relative to placebo. Low doses of CBD when combined with THC enhanced, while high doses of CBD reduced the intoxicating effects of THC. The enhancement of intoxication by low-dose CBD was particularly prominent in infrequent cannabis users and was consistent across objective and subjective measures. Most effects were significant at p < .0001.

These findings are important to consider in terms of recommended proportions of THC and CBD in cannabis plant matter whether used medicinally or recreationally and have implications for novice or less experienced cannabis users.

 

[SweetSue]

Source

Original Paper Published: 19 January 2019

A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects


Nadia Solowij, Samantha Broyd, Rodney Croft

European Archives of Psychiatry and Clinical Neuroscience, volume 269, pages 17- 35(2019)

Abstract

Access to cannabis and cannabinoid products is increasing worldwide for recreational and medicinal use. Two primary compounds within cannabis plant matter, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are both psychoactive, but only THC is considered intoxicating. There is significant interest in potential therapeutic properties of these cannabinoids and of CBD in particular.

Some research has suggested that CBD may ameliorate adverse effects of THC, but this may be dose dependent as other evidence suggests possible potentiating effects of THC by low doses of CBD. We conducted a randomised placebo controlled trial to examine the acute effects of these compounds alone and in combination when administered by vaporisation to frequent and infrequent cannabis users. Participants (n = 36; 31 male) completed 5 drug conditions spaced one week apart, with the following planned contrasts: placebo vs CBD alone (400 mg); THC alone (8 mg) vs THC combined with low (4 mg) or high (400 mg) doses of CBD. Objective (blind observer ratings) and subjective (self-rated) measures of intoxication were the primary outcomes, with additional indices of intoxication examined. CBD showed some intoxicating properties relative to placebo. Low doses of CBD when combined with THC enhanced, while high doses of CBD reduced the intoxicating effects of THC. The enhancement of intoxication by low-dose CBD was particularly prominent in infrequent cannabis users and was consistent across objective and subjective measures. Most effects were significant at p < .0001.

These findings are important to consider in terms of recommended proportions of THC and CBD in cannabis plant matter whether used medicinally or recreationally and have implications for novice or less experienced cannabis users.


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Via the European Archives of Psychiatry and Clinical Neuroscience.

 

[SweetSue]

Looking at it through new eyes......


New Patient Dosing Guidelines by Russo and MacCallum

THC and CBD together

A 2010 report British Journal Of Pharmacology had a report on clinical trials that demonstrated CBD will potential THC

• Adding CBD to an ineffective low dose of THC will make it effective.
• With CBD added you can get medicinal benefits of THC at lower doses.

Journal Of Pain study of Sativex:

• 263 cancer patients not getting relief with opioids
• broken into 3 groups
  • A) 21 mg Sativex/day = significant improvement
  • B) 52 mg/day = less significant improvement
  • C) 83 mg/day = no better than placebo with more adverse effects

When high THC is needed, balance it with high CBD to tamp down psychoactive effects.


There are questions that arise:

• Was that a daily dose, given all at once, or microdosed across the day? It would have made a difference.
• I‘d like to know what those adverse effects were, specifically.
• This was cancer patients, not chronic pain patients, but I think we can safely extrapolate the findings.
• There's a strong suggestion here that it’s particularly beneficial for pain patients to find the minimal effective dose and try to stick with it as much as possible. Plan your euphoric moments wisely if you’re using cannabis for pain management.
  

If those adverse side effects are euphoria, and you’re ok with feeling really good while you’re healing, and it won’t interfere with your social obligations, then euphoria becomes a benefit.

Cannabis - Multi-Tasking Medicine At Its Best. ​

 

[SweetSue]

From Iowa Medical Marijuana.Org , a study from 2010:

Source

Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Studyof the Efficacy, Safety, and Tolerabilityof THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain

Jeremy R. Johnson, MB ChB, Mary Burnell-Nugent, MB BChir,

Dominique Lossignol, MB ChB, MRCG, DRCOG,

Elena Doina Ganae-Motan, MD, Richard Potts, BSc (Hons), MICR, and

Marie T. Fallon, MB ChB, MD, FRCP (E), FRCP (Glasg)

Severn Hospice (J.R.J.), Shrewsbury, Shropshire, and St. Luke’s Hospice (M.B.-N.), Turnchapel, Plymouth, United Kingdom; Association Hospitaliere De Brussels (D.L.), Centre des Tumeurs de l’ULB, Brussels, Belgium; Emergency Department (E.D.G.-M.), Hospital ‘‘Sf. Ioan cel Nou,’’ Suceava, Romania; GW Pharma Ltd. (R.P.), Ely, Cambridgeshire; and Edinburgh Cancer Research Centre (M.T.F.), University of Edinburgh, Edinburgh, United Kingdom

[...]

The study medication was delivered using a pump action oromucosal spray.

• Each 100- mL actuation of the pump containing the THC:CBD extract delivered a dose containing 2.7 mg THC and 2.5 mg CBD.
• Each 100-mL ac- tuation of the pump containing the THC ex- tract delivered a dose containing 2.7 mg THC,
• and each actuation of placebo delivered only excipients plus colorants.
• The maximum permitted dose of all study medication was eight actuations in any three-hour period and
  • 48 actuations in any 24-hour period.

Patients self-titrated to their optimal dose over the seven days of Week 1,
based on

• efficacy,
• tolerability, and
• the maximum permitted dose.

Patients could increase the total number of sprays each day by a maximum of 50% until they either

• had satisfactory relief of their symp- toms or
• developed unwanted effects, such as intoxication (‘‘high’’).

The total number of sprays was spread over the day with a minimum of 15 minutes between any two sprays.

• If unwanted effects developed on a new number of sprays, the patient would not take any further sprays for three to four hours.
• The patient would then go back to taking their further sprays at a similar level to the previous day.

Once the patient had found

• the maximum number of sprays per day that they tolerated well
• or the number that provided good symptom relief,

they continued with approximately the same number of sprays per day for the remainder of the study.

The THC:CBD and the THC medications
were well tolerated.

Patients were fully titrated at one week and maintained stable dosing throughout the treatment period, that is, there was no observed tendency to increase dose with time.

• This corresponded to a reduction in pain NRS score over the same period.

The clinical response to pain with THC:CBD extract oromucosal spray has not demonstrated tolerance in several clinical trials of longer duration.

There is evidence of synergy between THC and morphine in pain, and THC may modulate endogenous opioid tone.

However, in this study, the THC:CBD combination showed a more promising efficacy profile than the THC alone.

This finding is supported by evidence of additional synergy between THC and CBD.

• CBD may enhance the analgesic potential of THC by means of potent inverse agonism at CB2 receptors,14 which may produce anti-inflammatory effects, along with its ability to inhibit immune cell migration.
• Additionally, CBD may modulate the potential unwanted effects of THC by means of antagonism at CB1 receptors
• which potentially would provide a better safety profile for the THC:CBD medication in chronic use

In conclusion, THC:CBD extract, a nonopioid analgesic, endocannabinoid system modulator, has been shown to be a useful adjunctive treatment for relief of pain in patients with advanced cancer who experience inadequate analgesia despite chronic opioid therapy.

The reductions in pain scores were neither

• because of a change in opioid background medications
• nor because of an increase in use of break- through medication.

Therefore, we can conclude that the observed reduction in pain scores is attributable to the positive analgesic effects of THC:CBD extract.

These results are very encouraging and merit further study.

 

[Amy Gardner]

Thanks for sharing all your study notes like this Sue. It’s like having access to really great lecture notes! I have to cherry pick the stuff i dive into but i nearly always come across something exactly relevant to my current lines of thinking or current wonderings.

Got look at the website. Looks nice. Not cheap. Could be worth it.

It is

Emerging patterns of specific ratios for disease - For a novice patient

These notes are particularly excellent and reflect my personal clinical experience. Do you also have the source link for this stuff?

I’ve begun wondering lately with all the current hoopla about euphoria and topicals if there’s been any cases of this actually occurring?
If anyone reading this hears of one I’d appreciate a ”heads up!”

I have! I know 2 people who claim some kind of intoxication from THC topical application To the MDR (gee i hope i got that right this time ).

They are both self-confessedly super sensitive people, so it may have been fairly mild. BUt it was certainly something they felt enough to want to mention - and for one it was enough to be wary of it afterwards. I regretted having been so generous with the application!

’ve been wondering about this myself, because I know athletes who’ve used CBD creams and had great relief, but none of them could produce a jar with any useful information on it, so it remains a mystery.

Timing would have it I tried some freshly made CBD oil (about 8mg/ml) on a pinched nerve spot this morning, just to see and I am sure it worked about the same as my THC topical. My current batch of topical has some amount of CBD in it and is reportedly a little more effective than teh last one. Clinically there seems ot be something in it indeed. Next I’ll try a 1:1 topical and see if it’s the magic pain ratio there as well.

I wouldn’t usually post so much in your study notebook sorry Sue - I seem to be super chatty today, and I have been catching up a lot and having my thoughts triggered

 

[SweetSue]

Thanks for sharing all your study notes like this Sue. It’s like having access to really great lecture notes! I have to cherry pick the stuff i dive into but i nearly always come across something exactly relevant to my current lines of thinking or current wonderings.

It is

These notes are particularly excellent and reflect my personal clinical experience. Do you also have the source link for this stuff?


I have! I know 2 people who claim some kind of intoxication from THC topical application To the MDR (gee i hope i got that right this time ).

They are both self-confessedly super sensitive people, so it may have been fairly mild. BUt it was certainly something they felt enough to want to mention - and for one it was enough to be wary of it afterwards. I regretted having been so generous with the application!

Timing would have it I tried some freshly made CBD oil (about 8mg/ml) on a pinched nerve spot this morning, just to see and I am sure it worked about the same as my THC topical. My current batch of topical has some amount of CBD in it and is reportedly a little more effective than teh last one. Clinically there seems ot be something in it indeed. Next I’ll try a 1:1 topical and see if it’s the magic pain ratio there as well.

I wouldn’t usually post so much in your study notebook sorry Sue - I seem to be super chatty today, and I have been catching up a lot and having my thoughts triggered

By gosh girl, you post your thoughts anytime.

OK, caution with topicals. Hmmm.... rethink the narratives and be upfront with everyone. One of the topical companies says right up front something to the effect of “This is a cannabis product and should be treated as such.” They’re right.

And thank you for testing the CBD oils. I’ll keep an eye out for the results of the 1:1.

I so love to have verification from someone I trust. Everyone seems to be selling something in the cannabis space and I’m leery enough I want to hear it from friends.

Before cannabis was pushed underground and became more recreational drug than medicinal plant the plants expressed higher CBD values, I’m certain of it. In all likelihood it was the rare plant that had higher THC, until we humans began playing with genetics.

It’s fun watching it shift back and expand to other cannabinoid expressions through creative breeding. I think it’ll be a whole new playground in another 20 years.

See? I get talky around here too sometimes.

 

[SweetSue]

@Amy Gardner, the reference and link you were asking for was Project CBD’s CBD User’s Guide

 

[InTheShed]

A low dose of local anesthesia applied to peripheral nerves blocks the unmyelinated C fibers before the myelinated A delta fibers. Under this condition, the slow conducting pain information is blocked, and only the fast conducting pain information by A delta fibers is carried to the CNS. This experiment provides additional evidence that two different types of nerve fibers carry noxious information.

So the unmyelinated C fibers is what we are targeting at the MDR (correct Amy!), and that targets the specific types of pain in 1 and 2 below:

1. Burning pain or soreness pain. Pain caused by inflammation, burned skin, etc., is carried by the C fibers (slowly conducted pain nerve fibers). This type of pain is a more diffuse, slower to onset, and longer in duration. It is an annoying pain and intolerable pain, which is not distinctly localized. Like pricking pain, burning pain arises mainly from the skin. It is carried by the paleospinothalamic tract. (The old primitive transmission system for diffuse pain which does not permit exact localization.)
2. Aching pain is a sore pain. This pain arises mainly from the viscera and somatic deep structures. Aching pain is not distinctly localized and is an annoying and intolerable pain. Aching pain is carried by the C fibers from the deep structures to the spinal cord.

Each 100- mL actuation of the pump containing the THC:CBD extract delivered a dose containing 2.7 mg THC and 2.5 mg CBD.

Close enough to 1:1 in my book!

vs THC combined with low (4 mg) or high (400 mg) doses of CBD.

400mg is a really really high amount of CBD! And the chart seemed to indicate very little difference between subjective effects of THC vs THC/low CBD. I would call is statistically insignificant, particularly since it was subjectively measured.