Defol for me is like an ongoing, never ending, experiment. What I'm doing now is removing all those tiny bud sites, but leaving all leaves. I'm trying to train the plants to where there's no need to trim, and that old getting light to bottom buds, well as far as I'm concerned, there's no reason for bottom buds, ever, as they don't add up to almost nothing. But there's no good reason to remove a leaf, unless it's going to touch the soil. I have heavily defoiled before with decent results, but I think yield will be better with more solar panels.
Who would have thought, that at 76, I'd be trying to figure out how to grow a dam weed.