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- #41
Peat Phreak
Well-Known Member
Body Wisdom dictates that there are no ECS receptors on the Cardiac & Respiratory cells in the brain stem....this is just one of the reasons for the high safety margin of the plant.
Feeling so blessed to receive a message from Sister Vee <3
However, I have some science here that contradicts your Body Wisdom.
The CB1 receptor is mainly expressed in the brain in areas of primary sensory and motor regions as well as areas of memory, cognition, and emotion, all of which overlap the areas of the autonomic nervous system and neuroendocrine system [1].
Kano et al. suggested that the highest levels of CB1 receptor binding were observed in the olfactory bulb, as well as in the regions of the dentate gyrus, the lateral striatum, the globus pallidus, the entopeduncular nucleus, the substantia nigra (SN) pars reticulata, and the cerebellar molecular layer [2].
Moderate levels were found in the frontal, parietal, and cingulate regions, in the amygdala, in the ventromedial hypothalamus, in the parabrachial nucleus, in the nucleus of the solitary tract, and in the spinal dorsal horn [2].
Low levels of CB1 receptor were found at the level of the thalamus and at the level of the brain stem nuclei [2].
Physiology of the Endocannabinoid System
The endocannabinoid system (ECS) is involved in various processes, including brain plasticity, learning and memory, neuronal development, nociception, inflammation, appetite regulation, digestion, metabolism, energy balance, motility, and regulation of stress and emotions.
encyclopedia.pub
But it doesn't matter what kind of receptors the brain stem has. THC is in the bloodstream. THC is causing inflamation in the arteries which causes plaque build up. Which causes coronary artery disease at a rate of 34% higher than not using weed daily according to the study in the OP.
Heavy daily users probably have more than a 34% increase in risk. They lumped all daily users into one group that averaged out to 34%. There is probably a big difference between 1 gram a day and 5 grams a day. Some people use more than that.